Expression of VWA8 in cancer - Summary - The Human Protein Atlas

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VWA8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	VWA8
Gene description	Von Willebrand factor A domain containing 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Generla cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA039075 , HPA045478
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039075	HPA045478

GENE INFORMATION
Gene name	VWA8 (HGNC Symbol)
Synonyms	KIAA0564
Description	Von Willebrand factor A domain containing 8 (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q14.11
Chromosome location (bp)	41566837 - 41961120
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102763 (version 83.38)
Entrez gene	23078
UniProt	A3KMH1 (UniProt - Evidence at protein level)
neXtProt	NX_A3KMH1
Antibodypedia	VWA8 antibodies

PROTEIN BROWSER

VWA8-002	VWA8-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VWA8-002 ENSP00000281496 ENST00000281496	A3KMH1 [Direct mapping] von Willebrand factor A domain-containing protein 8 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	1039 aa 116.9 kDa	No	0
VWA8-005 ENSP00000368612 ENST00000379310	A3KMH1 [Direct mapping] von Willebrand factor A domain-containing protein 8 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016887 [ATPase activity] Show all	1905 aa 214.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.