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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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IRG1
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

IRG1

Gene description

Immunoresponsive 1 homolog (mouse)

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (appendix)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining in cells/structures not annotated, view images.

Reliability score

Uncertain based on 1 antibody.
HPA040143
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA040143

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

All cancer tissues were negative.

GENE INFORMATION

Gene name

IRG1

Synonyms

Description

Immunoresponsive 1 homolog (mouse) (HGNC Symbol)

Entrez gene summary

Chromosome

13

Cytoband

q22.3

Chromosome location (bp)

76948497 - 76958642

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102794 (version 83.38)

Entrez gene

730249

UniProt

A6NK06 (UniProt - Evidence at protein level)

neXtProt

NX_A6NK06

Antibodypedia

IRG1 antibodies

PROTEIN BROWSER

IRG1-001
IRG1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IRG1-001
ENSP00000366682
ENST00000377462
A6NK06 [Direct mapping]
Cis-aconitate decarboxylase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Show all
GO:0002760 [positive regulation of antimicrobial humoral response]
GO:0005739 [mitochondrion]
GO:0006952 [defense response]
GO:0006954 [inflammatory response]
GO:0007566 [embryo implantation]
GO:0008152 [metabolic process]
GO:0016829 [lyase activity]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032480 [negative regulation of type I interferon production]
GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway]
GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway]
GO:0035458 [cellular response to interferon-beta]
GO:0045824 [negative regulation of innate immune response]
GO:0047613 [aconitate decarboxylase activity]
GO:0050728 [negative regulation of inflammatory response]
GO:0071219 [cellular response to molecule of bacterial origin]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071346 [cellular response to interferon-gamma]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071393 [cellular response to progesterone stimulus]
GO:0072573 [tolerance induction to lipopolysaccharide]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
481 aa
52.6 kDa
No 0
IRG1-201
ENSP00000401584
ENST00000449753
H7C1Q4 [Direct mapping]
Cis-aconitate decarboxylase
Show all
Predicted intracellular proteins
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0016829 [lyase activity]
Show all
481 aa
52.6 kDa
No 0

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