Expression of ELMO3 in cancer - Summary - The Human Protein Atlas

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ELMO3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ELMO3
Gene description	Engulfment and cell motility 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, HaCaT, T-47d)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA021484
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021484

GENE INFORMATION
Gene name	ELMO3 (HGNC Symbol)
Synonyms	CED-12, CED12, ELMO-3, FLJ13824
Description	Engulfment and cell motility 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67199111 - 67204029
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102890 (version 83.38)
Entrez gene	79767
UniProt	Q96BJ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BJ8
Antibodypedia	ELMO3 antibodies

PROTEIN BROWSER

ELMO3-001	ELMO3-002	ELMO3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ELMO3-001 ENSP00000354077 ENST00000360833	F8W9E7 [Direct mapping] Engulfment and cell motility protein 3 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0016477 [cell migration] Show all	756 aa 85.3 kDa	No	0
ELMO3-002 ENSP00000458539 ENST00000477898	Q96BJ8 [Direct mapping] Engulfment and cell motility protein 3 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006909 [phagocytosis] GO:0006915 [apoptotic process] GO:0016477 [cell migration] GO:0017124 [SH3 domain binding] Show all	607 aa 68.9 kDa	No	0
ELMO3-003 ENSP00000377566 ENST00000393997	Q96BJ8 [Direct mapping] Engulfment and cell motility protein 3 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006909 [phagocytosis] GO:0006915 [apoptotic process] GO:0016477 [cell migration] GO:0017124 [SH3 domain binding] Show all	773 aa 87.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.