Expression of NUP93 in cancer - Summary - The Human Protein Atlas

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NUP93

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NUP93
Gene description	Nucleoporin 93kDa
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Sub cellular location is contradicted by external data.
Reliability score	Uncertain based on 1 antibody. HPA017937
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017937

GENE INFORMATION
Gene name	NUP93 (HGNC Symbol)
Synonyms	KIAA0095
Description	Nucleoporin 93kDa (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q13
Chromosome location (bp)	56730105 - 56850286
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102900 (version 83.38)
Entrez gene	9688
UniProt	Q8N1F7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N1F7
Antibodypedia	NUP93 antibodies

PROTEIN BROWSER

NUP93-001	NUP93-002	NUP93-003	NUP93-004	NUP93-007	NUP93-008	NUP93-011	NUP93-013	NUP93-016	NUP93-017	NUP93-018	NUP93-019	NUP93-020	NUP93-021	NUP93-022	NUP93-023

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUP93-001 ENSP00000310668 ENST00000308159	Q8N1F7 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0002230 [positive regulation of defense response to virus by host] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005975 [carbohydrate metabolic process] GO:0006606 [protein import into nucleus] GO:0006810 [transport] GO:0007077 [mitotic nuclear envelope disassembly] GO:0008033 [tRNA processing] GO:0008645 [hexose transport] GO:0010467 [gene expression] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016925 [protein sumoylation] GO:0016973 [poly(A)+ mRNA export from nucleus] GO:0017056 [structural constituent of nuclear pore] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019054 [modulation by virus of host process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019221 [cytokine-mediated signaling pathway] GO:0031047 [gene silencing by RNA] GO:0031965 [nuclear membrane] GO:0034399 [nuclear periphery] GO:0034605 [cellular response to heat] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0051292 [nuclear pore complex assembly] GO:0055085 [transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] GO:1900034 [regulation of cellular response to heat] Show all	819 aa 93.5 kDa	No	1
NUP93-002 ENSP00000458101 ENST00000569842	H3BVG0 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0006810 [transport] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	880 aa 99.6 kDa	No	1
NUP93-003 ENSP00000458039 ENST00000564887	Q8N1F7 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0002230 [positive regulation of defense response to virus by host] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005975 [carbohydrate metabolic process] GO:0006606 [protein import into nucleus] GO:0006810 [transport] GO:0007077 [mitotic nuclear envelope disassembly] GO:0008033 [tRNA processing] GO:0008645 [hexose transport] GO:0010467 [gene expression] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016925 [protein sumoylation] GO:0016973 [poly(A)+ mRNA export from nucleus] GO:0017056 [structural constituent of nuclear pore] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019054 [modulation by virus of host process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019221 [cytokine-mediated signaling pathway] GO:0031047 [gene silencing by RNA] GO:0031965 [nuclear membrane] GO:0034399 [nuclear periphery] GO:0034605 [cellular response to heat] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0051292 [nuclear pore complex assembly] GO:0055085 [transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] GO:1900034 [regulation of cellular response to heat] Show all	696 aa 79.9 kDa	No	1
NUP93-004 ENSP00000440235 ENST00000542526	Q8N1F7 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0002230 [positive regulation of defense response to virus by host] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005975 [carbohydrate metabolic process] GO:0006606 [protein import into nucleus] GO:0006810 [transport] GO:0007077 [mitotic nuclear envelope disassembly] GO:0008033 [tRNA processing] GO:0008645 [hexose transport] GO:0010467 [gene expression] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016925 [protein sumoylation] GO:0016973 [poly(A)+ mRNA export from nucleus] GO:0017056 [structural constituent of nuclear pore] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019054 [modulation by virus of host process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019221 [cytokine-mediated signaling pathway] GO:0031047 [gene silencing by RNA] GO:0031965 [nuclear membrane] GO:0034399 [nuclear periphery] GO:0034605 [cellular response to heat] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0051292 [nuclear pore complex assembly] GO:0055085 [transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] GO:1900034 [regulation of cellular response to heat] Show all	696 aa 79.9 kDa	No	1
NUP93-007 ENSP00000456196 ENST00000563486	H3BRD9 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0006810 [transport] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	140 aa 15.8 kDa	No	0
NUP93-008 ENSP00000458078 ENST00000563405	H3BVE2 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0006810 [transport] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	117 aa 13.1 kDa	No	0
NUP93-011 ENSP00000457907 ENST00000569322	H3BV15 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0006810 [transport] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	84 aa 9.8 kDa	No	0
NUP93-013 ENSP00000454935 ENST00000566678	H3BNN5 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	132 aa 14.8 kDa	No	0
NUP93-016 ENSP00000455181 ENST00000567081	H3BP72 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006606 [protein import into nucleus] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	17 aa 2.2 kDa	No	0
NUP93-017 ENSP00000454844 ENST00000568283	H3BNG7 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006606 [protein import into nucleus] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	40 aa 4.8 kDa	No	0
NUP93-018 ENSP00000455210 ENST00000567641	H3BP95 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0006810 [transport] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	156 aa 17.8 kDa	No	0
NUP93-019 ENSP00000454285 ENST00000568656	H3BM93 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	178 aa 19.9 kDa	No	0
NUP93-020 ENSP00000456264 ENST00000566315	H3BRI8 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	151 aa 17 kDa	No	0
NUP93-021 ENSP00000457902 ENST00000562496	H3BV11 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	136 aa 15.2 kDa	No	0
NUP93-022 ENSP00000454587 ENST00000569863	H3BMX0 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	125 aa 14.1 kDa	No	0
NUP93-023 ENSP00000455230 ENST00000563858	H3BPA9 [Direct mapping] Nuclear pore complex protein Nup93 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005643 [nuclear pore] GO:0006606 [protein import into nucleus] GO:0006810 [transport] GO:0016973 [poly(A)+ mRNA export from nucleus] Show all	230 aa 26.4 kDa	No	0

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