Fields »
ABOUT
HELP
BLOG
LONP2

GENERAL INFORMATION

Gene name

 LONP2

Gene description

 Lon peptidase 2, peroxisomal

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Sub cellular location is contradicted by external data.

Reliability score

 Uncertain based on 1 antibody.
HPA008862
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (unfavourable).
Renal cancer p<0.001
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008862

GENE INFORMATION

Gene name

 LONP2 (HGNC Symbol)

Synonyms

 LONP, LONPL, MGC4840

Description

 Lon peptidase 2, peroxisomal (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 q12.1

Chromosome location (bp)

 48244296 - 48363122

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102910 (version 83.38)

Entrez gene

 83752

UniProt

 Q86WA8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86WA8

Antibodypedia

 LONP2 antibodies

PROTEIN BROWSER
LONP2-001
LONP2-003
LONP2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LONP2-001
ENSP00000285737
ENST00000285737
Q86WA8 [Direct mapping]
Lon protease homolog 2, peroxisomal
Show all
Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004176 [ATP-dependent peptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006508 [proteolysis]
GO:0006515 [misfolded or incompletely synthesized protein catabolic process]
GO:0006625 [protein targeting to peroxisome]
GO:0007031 [peroxisome organization]
GO:0008233 [peptidase activity]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016485 [protein processing]
GO:0016558 [protein import into peroxisome matrix]
GO:0019899 [enzyme binding]
GO:0031998 [regulation of fatty acid beta-oxidation]
Show all
 852 aa
94.6 kDa 		No 0
LONP2-003
ENSP00000445426
ENST00000535754
Q86WA8 [Direct mapping]
Lon protease homolog 2, peroxisomal
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0004176 [ATP-dependent peptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006508 [proteolysis]
GO:0006515 [misfolded or incompletely synthesized protein catabolic process]
GO:0006625 [protein targeting to peroxisome]
GO:0007031 [peroxisome organization]
GO:0008233 [peptidase activity]
GO:0016020 [membrane]
GO:0016485 [protein processing]
GO:0016558 [protein import into peroxisome matrix]
GO:0019899 [enzyme binding]
GO:0031998 [regulation of fatty acid beta-oxidation]
Show all
 808 aa
89.7 kDa 		No 0
LONP2-007
ENSP00000455297
ENST00000565867
H3BPF7 [Direct mapping]
Lon protease homolog 2, peroxisomal
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004176 [ATP-dependent peptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005782 [peroxisomal matrix]
GO:0006508 [proteolysis]
GO:0006515 [misfolded or incompletely synthesized protein catabolic process]
Show all
 236 aa
25.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.