Expression of N4BP1 in cancer - Summary - The Human Protein Atlas

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N4BP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	N4BP1
Gene description	NEDD4 binding protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA040849 , HPA041080
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040849	HPA041080

GENE INFORMATION
Gene name	N4BP1
Synonyms
Description	NEDD4 binding protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q12.1
Chromosome location (bp)	48538726 - 48620148
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102921 (version 83.38)
Entrez gene	9683
UniProt	O75113 (UniProt - Evidence at protein level)
neXtProt	NX_O75113
Antibodypedia	N4BP1 antibodies

PROTEIN BROWSER

N4BP1-001	N4BP1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
N4BP1-001 ENSP00000262384 ENST00000262384	O75113 [Direct mapping] NEDD4-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0016605 [PML body] GO:0031397 [negative regulation of protein ubiquitination] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034644 [cellular response to UV] Show all	896 aa 100.4 kDa	No	0
N4BP1-006 ENSP00000460667 ENST00000564710	I3L3R7 [Direct mapping] NEDD4-binding protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		142 aa 16 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.