Tissue expression of ZNF423 - Summary - The Human Protein Atlas

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ZNF423

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ZNF423
Gene description	Zinc finger protein 423
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending retesting. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA015258
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	ZNF423 (HGNC Symbol)
Synonyms	Ebfaz, JBTS19, KIAA0760, NPHP14, OAZ, Roaz, Zfp104
Description	Zinc finger protein 423 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012]
Chromosome	16
Cytoband	q12.1
Chromosome location (bp)	49487524 - 49857919
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000102935 (version 83.38)
Entrez gene	23090
UniProt	Q2M1K9 (UniProt - Evidence at protein level)
neXtProt	NX_Q2M1K9
Antibodypedia	ZNF423 antibodies

PROTEIN BROWSER

ZNF423-001	ZNF423-002	ZNF423-003	ZNF423-004	ZNF423-005	ZNF423-006	ZNF423-008	ZNF423-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF423-001 ENSP00000455426 ENST00000561648	Q2M1K9 [Direct mapping] Zinc finger protein 423 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007219 [Notch signaling pathway] GO:0007399 [nervous system development] GO:0030154 [cell differentiation] GO:0030513 [positive regulation of BMP signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1284 aa 144.6 kDa	No	0
ZNF423-002 ENSP00000457664 ENST00000562520	Q2M1K9 [Direct mapping] Zinc finger protein 423 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007219 [Notch signaling pathway] GO:0007399 [nervous system development] GO:0030154 [cell differentiation] GO:0030513 [positive regulation of BMP signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1224 aa 138 kDa	No	0
ZNF423-003 ENSP00000455588 ENST00000563137	Q2M1K9 [Direct mapping] Zinc finger protein 423 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007219 [Notch signaling pathway] GO:0007399 [nervous system development] GO:0030154 [cell differentiation] GO:0030513 [positive regulation of BMP signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1224 aa 138 kDa	No	0
ZNF423-004 ENSP00000442321 ENST00000535559	F5H7S1 [Direct mapping] Zinc finger protein 423 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	1167 aa 131.7 kDa	No	0
ZNF423-005 ENSP00000457928 ENST00000562871	Q2M1K9 [Direct mapping] Zinc finger protein 423 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007219 [Notch signaling pathway] GO:0007399 [nervous system development] GO:0030154 [cell differentiation] GO:0030513 [positive regulation of BMP signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1224 aa 138 kDa	No	0
ZNF423-006 ENSP00000479288 ENST00000568094	A0A087WV99 [Direct mapping] Zinc finger protein 423 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		102 aa 11.3 kDa	No	0
ZNF423-008 ENSP00000455061 ENST00000567169	F5H7S1 [Direct mapping] Zinc finger protein 423 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0046872 [metal ion binding] Show all	1167 aa 131.7 kDa	No	0
ZNF423-201 ENSP00000262383 ENST00000262383	Q2M1K9 [Direct mapping] Zinc finger protein 423 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007219 [Notch signaling pathway] GO:0007399 [nervous system development] GO:0030154 [cell differentiation] GO:0030513 [positive regulation of BMP signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	1284 aa 144.6 kDa	No	0

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The Human Protein Atlas

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