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POLR2C

GENERAL INFORMATION

Gene name

 POLR2C

Gene description

 Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA040919 , HPA041826
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040919
HPA041826

GENE INFORMATION

Gene name

 POLR2C (HGNC Symbol)

Synonyms

 RPB3

Description

 Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q21

Chromosome location (bp)

 57462387 - 57472010

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102978 (version 83.38)

Entrez gene

 5432

UniProt

 P19387 (UniProt - Evidence at protein level)

neXtProt

 NX_P19387

Antibodypedia

 POLR2C antibodies

PROTEIN BROWSER
POLR2C-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR2C-001
ENSP00000219252
ENST00000219252
P19387 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB3
Q6FGR6 [Target identity:100%; Query identity:100%]
HCG2025883, isoform CRA_b; POLR2C protein; cDNA FLJ76636, highly similar to Homo sapiens polymerase (RNA) II (DNA directed) polypeptide C, 33kDa (POLR2C), transcript variant alpha, mRNA
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000398 [mRNA splicing, via spliceosome]
GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0046983 [protein dimerization activity]
GO:0050434 [positive regulation of viral transcription]
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 275 aa
31.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.