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MMP15

GENERAL INFORMATION

Gene name

 MMP15

Gene description

 Matrix metallopeptidase 15 (membrane-inserted)

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO, WM-115)
HPA (normal tissue):Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA040390 , CAB002611
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA040390
CAB002611

GENE INFORMATION

Gene name

 MMP15 (HGNC Symbol)

Synonyms

 MT2-MMP, MTMMP2, SMCP-2

Description

 Matrix metallopeptidase 15 (membrane-inserted) (HGNC Symbol)

Entrez gene summary

 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q21

Chromosome location (bp)

 58025566 - 58046901

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000102996 (version 83.38)

Entrez gene

 4324

UniProt

 P51511 (UniProt - Evidence at protein level)

neXtProt

 NX_P51511

Antibodypedia

 MMP15 antibodies

PROTEIN BROWSER
MMP15-001
MMP15-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP15-001
ENSP00000219271
ENST00000219271
P51511 [Direct mapping]
Matrix metalloproteinase-15
A0A024R6U8 [Target identity:100%; Query identity:100%]
Matrix metallopeptidase 15 (Membrane-inserted), isoform CRA_a
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Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006464 [cellular protein modification process]
GO:0006508 [proteolysis]
GO:0008047 [enzyme activator activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0032355 [response to estradiol]
GO:0035987 [endodermal cell differentiation]
GO:0043085 [positive regulation of catalytic activity]
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 669 aa
75.8 kDa 		Yes 1
MMP15-002
ENSP00000457084
ENST00000570065
H3BT97 [Direct mapping]
Matrix metalloproteinase-15
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
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 97 aa
10.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.