Expression of SLC7A6 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SLC7A6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC7A6
Gene description	Solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA050713
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050713

GENE INFORMATION
Gene name	SLC7A6 (HGNC Symbol)
Synonyms	KIAA0245, LAT-2, LAT3, y+LAT-2
Description	Solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	68264516 - 68301823
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103064 (version 83.38)
Entrez gene	9057
UniProt	Q92536 (UniProt - Evidence at protein level)
neXtProt	NX_Q92536
Antibodypedia	SLC7A6 antibodies

PROTEIN BROWSER

SLC7A6-001	SLC7A6-003	SLC7A6-005	SLC7A6-006	SLC7A6-007	SLC7A6-008	SLC7A6-009	SLC7A6-014	SLC7A6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC7A6-001 ENSP00000219343 ENST00000219343	Q92536 [Direct mapping] Y+L amino acid transporter 2 A0A024R719 [Target identity:100%; Query identity:100%] Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 6, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0007596 [blood coagulation] GO:0015171 [amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	515 aa 56.8 kDa	No	>9
SLC7A6-003 ENSP00000455064 ENST00000566454	Q92536 [Direct mapping] Y+L amino acid transporter 2 A0A024R719 [Target identity:100%; Query identity:100%] Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 6, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006461 [protein complex assembly] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0007596 [blood coagulation] GO:0015171 [amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	515 aa 56.8 kDa	No	>9
SLC7A6-005 ENSP00000456896 ENST00000562727	H3BSV7 [Direct mapping] Y+L amino acid transporter 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	24 aa 2.7 kDa	No	0
SLC7A6-006 ENSP00000457550 ENST00000568024	H3BUA4 [Direct mapping] Y+L amino acid transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	123 aa 13 kDa	No	2
SLC7A6-007 ENSP00000457758 ENST00000566834	H3BUR2 [Direct mapping] Y+L amino acid transporter 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	98 aa 10.7 kDa	No	0
SLC7A6-008 ENSP00000455357 ENST00000568088	H3BPK5 [Direct mapping] Y+L amino acid transporter 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	28 aa 3.2 kDa	No	0
SLC7A6-009 ENSP00000456629 ENST00000564708	H3BSB6 [Direct mapping] Y+L amino acid transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	74 aa 8 kDa	No	1
SLC7A6-014 ENSP00000455487 ENST00000563146	H3BPV6 [Direct mapping] Y+L amino acid transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	92 aa 9.8 kDa	No	2
SLC7A6-201 ENSP00000484012 ENST00000618043	E7EPZ8 [Direct mapping] Y+L amino acid transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	229 aa 24.7 kDa	No	5

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.