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Cancer cells displayed weak to moderate cytoplasmic positivity. Additional nuclear staining in several cases. A majority of cases in skin, renal and cervical cancers were negative.
Weak to moderate cytoplasmic positivity was observed in most tissues. Additional nuclear and membranous staining in several cancer tissues. Few cases of basal cell carcinomas and squamous cell carcinomas were strongly positive.
GENE INFORMATION
Gene name
PLA2G15 (HGNC Symbol)
Synonyms
GXVPLA2, LLPL, LYPLA3
Description
Phospholipase A2, group XV (HGNC Symbol)
Entrez gene summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]