Expression of ESRP2 in cancer - Summary - The Human Protein Atlas

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ESRP2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ESRP2
Gene description	Epithelial splicing regulatory protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, MCF7, T-47d)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA048597
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048597

GENE INFORMATION
Gene name	ESRP2 (HGNC Symbol)
Synonyms	FLJ21918, RBM35B
Description	Epithelial splicing regulatory protein 2 (HGNC Symbol)
Entrez gene summary	ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	68229111 - 68238102
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103067 (version 83.38)
Entrez gene	80004
UniProt	Q9H6T0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6T0
Antibodypedia	ESRP2 antibodies

PROTEIN BROWSER

ESRP2-001	ESRP2-004	ESRP2-006	ESRP2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ESRP2-001 ENSP00000418748 ENST00000473183	Q9H6T0 [Direct mapping] Epithelial splicing regulatory protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003729 [mRNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] GO:0044822 [poly(A) RNA binding] Show all	717 aa 77.4 kDa	No	0
ESRP2-004 ENSP00000454554 ENST00000565858	Q9H6T0 [Direct mapping] Epithelial splicing regulatory protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003729 [mRNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] GO:0044822 [poly(A) RNA binding] Show all	727 aa 78.4 kDa	No	0
ESRP2-006 ENSP00000463770 ENST00000564382	J3QQJ9 [Direct mapping] Epithelial-splicing regulatory protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] Show all	82 aa 9.4 kDa	No	0
ESRP2-007 ENSP00000461970 ENST00000562724	J3KRF2 [Direct mapping] Epithelial-splicing regulatory protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 5.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.