Most cancer cells exhibited moderate cytoplasmic positivity. Several renal cancers as well as a few gastric and pancreatic cancers showed strong cytoplasmic staining. A majority of lymphomas, prostate and lung cancers were weakly stained or negative.
AXIN1 (HGNC Symbol)
Axin 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]