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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AXIN1
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AXIN1

Gene description

Axin 1

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB012987
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB012987

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells exhibited moderate cytoplasmic positivity. Several renal cancers as well as a few gastric and pancreatic cancers showed strong cytoplasmic staining. A majority of lymphomas, prostate and lung cancers were weakly stained or negative.

GENE INFORMATION

Gene name

AXIN1 (HGNC Symbol)

Synonyms

PPP1R49

Description

Axin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

287440 - 352673

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000103126 (version 83.38)

Entrez gene

8312

UniProt

O15169 (UniProt - Evidence at protein level)

neXtProt

NX_O15169

Antibodypedia

AXIN1 antibodies

PROTEIN BROWSER

AXIN1-001
AXIN1-002
AXIN1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AXIN1-001
ENSP00000262320
ENST00000262320
O15169 [Direct mapping]
Axin-1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0001701 [in utero embryonic development]
GO:0001743 [optic placode formation]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002039 [p53 binding]
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006913 [nucleocytoplasmic transport]
GO:0006915 [apoptotic process]
GO:0007257 [activation of JUN kinase activity]
GO:0007368 [determination of left/right symmetry]
GO:0007605 [sensory perception of sound]
GO:0008013 [beta-catenin binding]
GO:0008022 [protein C-terminus binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016055 [Wnt signaling pathway]
GO:0016328 [lateral plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0021797 [forebrain anterior/posterior pattern specification]
GO:0021881 [Wnt-activated signaling pathway involved in forebrain neuron fate commitment]
GO:0030154 [cell differentiation]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030163 [protein catabolic process]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway]
GO:0030877 [beta-catenin destruction complex]
GO:0030910 [olfactory placode formation]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032147 [activation of protein kinase activity]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032947 [protein complex scaffold]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0035412 [regulation of catenin import into nucleus]
GO:0036342 [post-anal tail morphogenesis]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0043621 [protein self-association]
GO:0043623 [cellular protein complex assembly]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046330 [positive regulation of JNK cascade]
GO:0046332 [SMAD binding]
GO:0048048 [embryonic eye morphogenesis]
GO:0048318 [axial mesoderm development]
GO:0048320 [axial mesoderm formation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051248 [negative regulation of protein metabolic process]
GO:0051260 [protein homooligomerization]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0055001 [muscle cell development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060272 [embryonic skeletal joint morphogenesis]
GO:0060823 [canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation]
GO:0070016 [armadillo repeat domain binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071514 [genetic imprinting]
GO:0071944 [cell periphery]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
862 aa
95.6 kDa
No 0
AXIN1-002
ENSP00000346935
ENST00000354866
O15169 [Direct mapping]
Axin-1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001743 [optic placode formation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006915 [apoptotic process]
GO:0007257 [activation of JUN kinase activity]
GO:0007368 [determination of left/right symmetry]
GO:0008013 [beta-catenin binding]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016328 [lateral plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021797 [forebrain anterior/posterior pattern specification]
GO:0021881 [Wnt-activated signaling pathway involved in forebrain neuron fate commitment]
GO:0030154 [cell differentiation]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030877 [beta-catenin destruction complex]
GO:0030910 [olfactory placode formation]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032147 [activation of protein kinase activity]
GO:0032947 [protein complex scaffold]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0035412 [regulation of catenin import into nucleus]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0043623 [cellular protein complex assembly]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046330 [positive regulation of JNK cascade]
GO:0046332 [SMAD binding]
GO:0048048 [embryonic eye morphogenesis]
GO:0048320 [axial mesoderm formation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051443 [positive regulation of ubiquitin-protein transferase activity]
GO:0055001 [muscle cell development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060272 [embryonic skeletal joint morphogenesis]
GO:0060823 [canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation]
GO:0070016 [armadillo repeat domain binding]
GO:0070411 [I-SMAD binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071944 [cell periphery]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
826 aa
91.7 kDa
No 0
AXIN1-005
ENSP00000416835
ENST00000457798
H0Y830 [Direct mapping]
Axin-1
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001743 [optic placode formation]
GO:0005096 [GTPase activator activity]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007257 [activation of JUN kinase activity]
GO:0007368 [determination of left/right symmetry]
GO:0008219 [cell death]
GO:0009950 [dorsal/ventral axis specification]
GO:0014069 [postsynaptic density]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019901 [protein kinase binding]
GO:0021797 [forebrain anterior/posterior pattern specification]
GO:0021881 [Wnt-activated signaling pathway involved in forebrain neuron fate commitment]
GO:0030154 [cell differentiation]
GO:0030910 [olfactory placode formation]
GO:0031122 [cytoplasmic microtubule organization]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0035412 [regulation of catenin import into nucleus]
GO:0043547 [positive regulation of GTPase activity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0048048 [embryonic eye morphogenesis]
GO:0048320 [axial mesoderm formation]
GO:0055001 [muscle cell development]
GO:0060272 [embryonic skeletal joint morphogenesis]
GO:0060823 [canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation]
GO:0070016 [armadillo repeat domain binding]
GO:0071407 [cellular response to organic cyclic compound]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090244 [Wnt signaling pathway involved in somitogenesis]
Show all
102 aa
11.4 kDa
No 0

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The Human Protein Atlas project is funded
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