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TAF1C

GENERAL INFORMATION

Gene name

 TAF1C

Gene description

 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TAF1C (HGNC Symbol)

Synonyms

 MGC:39976, SL1, TAFI110, TAFI95

Description

 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa (HGNC Symbol)

Entrez gene summary

 Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

Chromosome

 16

Cytoband

 q24.1

Chromosome location (bp)

 84177847 - 84187070

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103168 (version 83.38)

Entrez gene

 9013

UniProt

 Q15572 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15572

Antibodypedia

 TAF1C antibodies

PROTEIN BROWSER
TAF1C-001
TAF1C-002
TAF1C-003
TAF1C-005
TAF1C-011
TAF1C-014
TAF1C-015
TAF1C-021
TAF1C-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAF1C-001
ENSP00000455265
ENST00000567759
Q15572 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000120 [RNA polymerase I transcription factor complex]
GO:0000183 [chromatin silencing at rDNA]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 869 aa
95.2 kDa 		No 0
TAF1C-002
ENSP00000455933
ENST00000566732
Q15572 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000120 [RNA polymerase I transcription factor complex]
GO:0000183 [chromatin silencing at rDNA]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 843 aa
92.3 kDa 		No 0
TAF1C-003
ENSP00000455247
ENST00000570117
Q15572 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000120 [RNA polymerase I transcription factor complex]
GO:0000183 [chromatin silencing at rDNA]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 537 aa
58.4 kDa 		No 0
TAF1C-005
ENSP00000345305
ENST00000341690
Q15572 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000120 [RNA polymerase I transcription factor complex]
GO:0000183 [chromatin silencing at rDNA]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 775 aa
85 kDa 		No 0
TAF1C-011
ENSP00000454854
ENST00000564345
H3BNH3 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit C
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 146 aa
16.2 kDa 		No 0
TAF1C-014
ENSP00000457883
ENST00000564454
H3BUZ7 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 136 aa
15 kDa 		No 0
TAF1C-015
ENSP00000456011
ENST00000561955
H3BQZ8 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 94 aa
10.4 kDa 		No 0
TAF1C-021
ENSP00000456101
ENST00000568265
H3BR71 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 380 aa
41 kDa 		No 0
TAF1C-201
ENSP00000437900
ENST00000541676
Q15572 [Direct mapping]
TATA box-binding protein-associated factor RNA polymerase I subunit C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000120 [RNA polymerase I transcription factor complex]
GO:0000183 [chromatin silencing at rDNA]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
Show all
 537 aa
58.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.