Expression of NAGPA in cancer - Summary - The Human Protein Atlas

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NAGPA

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NAGPA
Gene description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA064055
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA064055

GENE INFORMATION
Gene name	NAGPA (HGNC Symbol)
Synonyms	APAA, UCE
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (HGNC Symbol)
Entrez gene summary	Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. [provided by RefSeq, Oct 2015]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	5024844 - 5034141
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103174 (version 83.38)
Entrez gene	51172
UniProt	Q9UK23 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UK23
Antibodypedia	NAGPA antibodies

PROTEIN BROWSER

NAGPA-001	NAGPA-005	NAGPA-007	NAGPA-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAGPA-001 ENSP00000310998 ENST00000312251	Q9UK23 [Direct mapping] N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003944 [N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity] GO:0005515 [protein binding] GO:0005975 [carbohydrate metabolic process] GO:0006464 [cellular protein modification process] GO:0006486 [protein glycosylation] GO:0006622 [protein targeting to lysosome] GO:0007040 [lysosome organization] GO:0016021 [integral component of membrane] GO:0032580 [Golgi cisterna membrane] Show all	515 aa 56.1 kDa	Yes	1
NAGPA-005 ENSP00000467385 ENST00000563578	K7EPH3 [Direct mapping] N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	315 aa 34 kDa	No	1
NAGPA-007 ENSP00000371381 ENST00000381955	Q9UK23 [Direct mapping] N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003944 [N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity] GO:0005515 [protein binding] GO:0005975 [carbohydrate metabolic process] GO:0006464 [cellular protein modification process] GO:0006486 [protein glycosylation] GO:0006622 [protein targeting to lysosome] GO:0007040 [lysosome organization] GO:0016021 [integral component of membrane] GO:0032580 [Golgi cisterna membrane] Show all	481 aa 52.4 kDa	Yes	1
NAGPA-019 ENSP00000468270 ENST00000562346	K7ERI4 [Direct mapping] N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		190 aa 20.2 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.