Fields »
ABOUT
HELP
BLOG
USP10

GENERAL INFORMATION

Gene name

 USP10

Gene description

 Ubiquitin specific peptidase 10

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA006731 , HPA006749
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA006731
HPA006749

GENE INFORMATION

Gene name

 USP10 (HGNC Symbol)

Synonyms

 KIAA0190, UBPO

Description

 Ubiquitin specific peptidase 10 (HGNC Symbol)

Entrez gene summary

 Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]

Chromosome

 16

Cytoband

 q24.1

Chromosome location (bp)

 84699978 - 84779922

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103194 (version 83.38)

Entrez gene

 9100

UniProt

 Q14694 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14694

Antibodypedia

 USP10 antibodies

PROTEIN BROWSER
USP10-001
USP10-004
USP10-008
USP10-013
USP10-014
USP10-015
USP10-017
USP10-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP10-001
ENSP00000219473
ENST00000219473
Q14694 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0006281 [DNA repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006914 [autophagy]
GO:0010506 [regulation of autophagy]
GO:0016579 [protein deubiquitination]
GO:0019985 [translesion synthesis]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0044822 [poly(A) RNA binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 798 aa
87.1 kDa 		No 0
USP10-004
ENSP00000457411
ENST00000570191
Q14694 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 10
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0006281 [DNA repair]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006914 [autophagy]
GO:0010506 [regulation of autophagy]
GO:0016579 [protein deubiquitination]
GO:0019985 [translesion synthesis]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0044325 [ion channel binding]
GO:0044822 [poly(A) RNA binding]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 802 aa
87.5 kDa 		No 0
USP10-008
ENSP00000458089
ENST00000563892
H3BVF1 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 158 aa
17.9 kDa 		No 0
USP10-013
ENSP00000455712
ENST00000562283
H3BQC6 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 141 aa
15.1 kDa 		No 0
USP10-014
ENSP00000462762
ENST00000569038
J3KT19 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016579 [protein deubiquitination]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 208 aa
23.4 kDa 		No 0
USP10-015
ENSP00000454751
ENST00000570053
H3BNA1 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0016579 [protein deubiquitination]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 150 aa
17 kDa 		No 0
USP10-017
ENSP00000454987
ENST00000569925
H3BNS8 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 76 aa
8.3 kDa 		No 0
USP10-018
ENSP00000455865
ENST00000567526
H3BQP1 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005622 [intracellular]
GO:0016579 [protein deubiquitination]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 110 aa
12.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.