Expression of ABCC1 in cancer - Summary

GENERAL INFORMATION
Gene name	ABCC1
Gene description	ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Protein class	Cancer-related genes FDA approved drug targets Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (EFO-21)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues, including seminiferous tubules in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA002380
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002380

GENE INFORMATION
Gene name	ABCC1 (HGNC Symbol)
Synonyms	GS-X, MRP, MRP1
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
Chromosome	16
Cytoband	p13.11
Chromosome location (bp)	15949577 - 16143074
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103222 (version 83.38)
Entrez gene	4363
UniProt	P33527 (UniProt - Evidence at protein level)
neXtProt	NX_P33527
Antibodypedia	ABCC1 antibodies

PROTEIN BROWSER

ABCC1-001	ABCC1-007	ABCC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCC1-001 ENSP00000382342 ENST00000399410	P33527 [Direct mapping] Multidrug resistance-associated protein 1 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006691 [leukotriene metabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0009235 [cobalamin metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016887 [ATPase activity] GO:0019369 [arachidonic acid metabolic process] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	1531 aa 171.6 kDa	No	>9
ABCC1-007 ENSP00000461615 ENST00000572882	I3L4X2 [Direct mapping] Multidrug resistance-associated protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	1440 aa 160.4 kDa	No	>9
ABCC1-201 ENSP00000382340 ENST00000399408	A0A0A0MS99 [Direct mapping] Multidrug resistance-associated protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0006810 [transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	1215 aa 135 kDa	No	>9