Expression of NOMO3 in cancer - Summary - The Human Protein Atlas

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NOMO3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NOMO3
Gene description	NODAL modulator 3
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA046697 , HPA061174
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046697	HPA061174

GENE INFORMATION
Gene name	NOMO3
Synonyms
Description	NODAL modulator 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.11
Chromosome location (bp)	16232495 - 16294814
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103226 (version 83.38)
Entrez gene	408050
UniProt	P69849 (UniProt - Inferred from homology)
neXtProt	NX_P69849
Antibodypedia	NOMO3 antibodies

PROTEIN BROWSER

NOMO3-001	NOMO3-003	NOMO3-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOMO3-001 ENSP00000382274 ENST00000399336	P69849 [Direct mapping] Nodal modulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1222 aa 134.1 kDa	Yes	1
NOMO3-003 ENSP00000263012 ENST00000263012	J3KN36 [Direct mapping] Nodal modulator 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0030246 [carbohydrate binding] Show all	1267 aa 139.4 kDa	Yes	1
NOMO3-015 ENSP00000459996 ENST00000570346	I3L2X2 [Direct mapping] Nodal modulator 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		50 aa 5.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.