Expression of NARFL in cancer - Summary - The Human Protein Atlas

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NARFL

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NARFL
Gene description	Nuclear prelamin A recognition factor-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA040851
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and renal cancer (favourable).
Cervical cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040851

GENE INFORMATION
Gene name	NARFL (HGNC Symbol)
Synonyms	FLJ21988, HPRN, IOP1, PRN
Description	Nuclear prelamin A recognition factor-like (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	729753 - 741329
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103245 (version 83.38)
Entrez gene	64428
UniProt	Q9H6Q4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6Q4
Antibodypedia	NARFL antibodies

PROTEIN BROWSER

NARFL-001	NARFL-005	NARFL-006	NARFL-010	NARFL-014	NARFL-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NARFL-001 ENSP00000251588 ENST00000251588	Q9H6Q4 [Direct mapping] Cytosolic Fe-S cluster assembly factor NARFL Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0016226 [iron-sulfur cluster assembly] GO:0032364 [oxygen homeostasis] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0097361 [CIA complex] Show all	476 aa 53 kDa	No	0
NARFL-005 ENSP00000444008 ENST00000540986	Q9H6Q4 [Direct mapping] Cytosolic Fe-S cluster assembly factor NARFL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0016226 [iron-sulfur cluster assembly] GO:0032364 [oxygen homeostasis] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0097361 [CIA complex] Show all	374 aa 42 kDa	No	0
NARFL-006 ENSP00000457058 ENST00000568545	Q9H6Q4 [Direct mapping] Cytosolic Fe-S cluster assembly factor NARFL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0016226 [iron-sulfur cluster assembly] GO:0032364 [oxygen homeostasis] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0097361 [CIA complex] Show all	374 aa 42 kDa	No	0
NARFL-010 ENSP00000459523 ENST00000566614	I3L2A3 [Direct mapping] Cytosolic Fe-S cluster assembly factor NARFL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0051536 [iron-sulfur cluster binding] Show all	53 aa 5.8 kDa	No	0
NARFL-014 ENSP00000456701 ENST00000562421	H3BSH2 [Direct mapping] Cytosolic Fe-S cluster assembly factor NARFL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0051536 [iron-sulfur cluster binding] Show all	186 aa 21.1 kDa	No	0
NARFL-019 ENSP00000456733 ENST00000567403	H3BSJ7 [Direct mapping] Cytosolic Fe-S cluster assembly factor NARFL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0051536 [iron-sulfur cluster binding] Show all	111 aa 12.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.