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CRYM

GENERAL INFORMATION

Gene name

 CRYM

Gene description

 Crystallin, mu

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, heart muscle, kidney, prostate, urinary bladder)
GTEx:Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5:Tissue enhanced (caudate, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including heart, CNS and kidney.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA019086 , HPA030619
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, heart muscle, kidney, prostate, urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebellum)

GENE INFORMATION

Gene name

 CRYM (HGNC Symbol)

Synonyms

 DFNA40

Description

 Crystallin, mu (HGNC Symbol)

Entrez gene summary

 Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014]

Chromosome

 16

Cytoband

 p12.2

Chromosome location (bp)

 21238874 - 21303083

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103316 (version 83.38)

Entrez gene

 1428

UniProt

 Q14894 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14894

Antibodypedia

 CRYM antibodies

PROTEIN BROWSER
CRYM-001
CRYM-003
CRYM-004
CRYM-005
CRYM-006
CRYM-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRYM-001
ENSP00000219599
ENST00000219599
Q14894 [Direct mapping]
Ketimine reductase mu-crystallin
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005782 [peroxisomal matrix]
GO:0006554 [lysine catabolic process]
GO:0007605 [sensory perception of sound]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042403 [thyroid hormone metabolic process]
GO:0042562 [hormone binding]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0047127 [thiomorpholine-carboxylate dehydrogenase activity]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070324 [thyroid hormone binding]
GO:0070327 [thyroid hormone transport]
Show all
 314 aa
33.8 kDa 		No 0
CRYM-003
ENSP00000460820
ENST00000570401
I3L3Y1 [Direct mapping]
Ketimine reductase mu-crystallin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 97 aa
10.4 kDa 		No 0
CRYM-004
ENSP00000460126
ENST00000576703
I3L325 [Direct mapping]
Ketimine reductase mu-crystallin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 241 aa
26.1 kDa 		No 0
CRYM-005
ENSP00000460510
ENST00000571358
I3L3J9 [Direct mapping]
Ketimine reductase mu-crystallin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 26 aa
2.8 kDa 		No 0
CRYM-006
ENSP00000461904
ENST00000572914
I3NI53 [Direct mapping]
Ketimine reductase mu-crystallin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 140 aa
14.8 kDa 		No 0
CRYM-201
ENSP00000440227
ENST00000543948
Q14894 [Direct mapping]
Ketimine reductase mu-crystallin
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0005737 [cytoplasm]
GO:0005782 [peroxisomal matrix]
GO:0006554 [lysine catabolic process]
GO:0007605 [sensory perception of sound]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0047127 [thiomorpholine-carboxylate dehydrogenase activity]
GO:0050661 [NADP binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070324 [thyroid hormone binding]
GO:0070327 [thyroid hormone transport]
Show all
 314 aa
33.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.