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This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases Atypical kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002931 [response to ischemia] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004686 [elongation factor-2 kinase activity] GO:0005509 [calcium ion binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006414 [translational elongation] GO:0006468 [protein phosphorylation] GO:0008135 [translation factor activity, RNA binding] GO:0008286 [insulin receptor signaling pathway] GO:0014069 [postsynaptic density] GO:0031952 [regulation of protein autophosphorylation] GO:0032869 [cellular response to insulin stimulus] GO:0043066 [negative regulation of apoptotic process] GO:0045807 [positive regulation of endocytosis] GO:0046777 [protein autophosphorylation] GO:0051965 [positive regulation of synapse assembly] GO:0061003 [positive regulation of dendritic spine morphogenesis] GO:0071277 [cellular response to calcium ion] GO:0071320 [cellular response to cAMP] GO:0071454 [cellular response to anoxia] GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus] GO:1990637 [response to prolactin]
