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ZNF174

GENERAL INFORMATION

Gene name

 ZNF174

Gene description

 Zinc finger protein 174

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA009656
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA009656

GENE INFORMATION

Gene name

 ZNF174 (HGNC Symbol)

Synonyms

 ZSCAN8

Description

 Zinc finger protein 174 (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 3401235 - 3409370

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103343 (version 83.38)

Entrez gene

 7727

UniProt

 Q15697 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15697

Antibodypedia

 ZNF174 antibodies

PROTEIN BROWSER
ZNF174-001
ZNF174-002
ZNF174-003
ZNF174-004
ZNF174-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZNF174-001
ENSP00000268655
ENST00000268655
Q15697 [Direct mapping]
Zinc finger protein 174
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0015629 [actin cytoskeleton]
GO:0042803 [protein homodimerization activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 407 aa
46.5 kDa 		No 0
ZNF174-002
ENSP00000339781
ENST00000344823
Q15697 [Direct mapping]
Zinc finger protein 174
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0015629 [actin cytoskeleton]
GO:0042803 [protein homodimerization activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 234 aa
26.9 kDa 		No 0
ZNF174-003
ENSP00000459681
ENST00000572544
I3L2H2 [Direct mapping]
Zinc finger protein 174
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Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0015629 [actin cytoskeleton]
Show all
 249 aa
28.6 kDa 		No 0
ZNF174-004
ENSP00000461502
ENST00000575752
Q15697 [Direct mapping]
Zinc finger protein 174
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0015629 [actin cytoskeleton]
GO:0042803 [protein homodimerization activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 234 aa
26.9 kDa 		No 0
ZNF174-005
ENSP00000460397
ENST00000571936
Q15697 [Direct mapping]
Zinc finger protein 174
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0015629 [actin cytoskeleton]
GO:0042803 [protein homodimerization activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 407 aa
46.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.