Expression of PRSS33 in cancer - Summary - The Human Protein Atlas

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PRSS33

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRSS33
Gene description	Protease, serine, 33
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (ovarian cancer)
HPA (cell line):	Group enriched (HMC-1, SK-MEL-30, U-2 OS)
HPA (normal tissue):	Tissue enriched (fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA058082
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA058082

GENE INFORMATION
Gene name	PRSS33 (HGNC Symbol)
Synonyms	EOS
Description	Protease, serine, 33 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2783953 - 2787948
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103355 (version 83.38)
Entrez gene	260429
UniProt	Q8NF86 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NF86
Antibodypedia	PRSS33 antibodies

PROTEIN BROWSER

PRSS33-001	PRSS33-002	PRSS33-003	PRSS33-004	PRSS33-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS33-001 ENSP00000458369 ENST00000570702	Q8NF86 [Direct mapping] Serine protease 33 Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	280 aa 29.8 kDa	Yes	0
PRSS33-002 ENSP00000459051 ENST00000576886	I3L1S0 [Direct mapping] Serine protease 33 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	115 aa 11.9 kDa	Yes	0
PRSS33-003 ENSP00000293851 ENST00000293851	Q8NF86 [Direct mapping] Serine protease 33 Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] Show all	280 aa 29.8 kDa	Yes	0
PRSS33-004 ENSP00000460368 ENST00000571674	I3L3D7 [Direct mapping] Serine protease 33 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	236 aa 25.4 kDa	Yes	0
PRSS33-201 ENSP00000483765 ENST00000612593	A0A087X0Z6 [Direct mapping] Serine protease 33 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	284 aa 30.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.