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EARS2

GENERAL INFORMATION

Gene name

 EARS2

Gene description

 Glutamyl-tRNA synthetase 2, mitochondrial

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA043289 , HPA043633
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043289
HPA043633

GENE INFORMATION

Gene name

 EARS2 (HGNC Symbol)

Synonyms

 KIAA1970, MSE1

Description

 Glutamyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Chromosome

 16

Cytoband

 p12.2

Chromosome location (bp)

 23522014 - 23557731

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103356 (version 83.38)

Entrez gene

 124454

UniProt

 Q5JPH6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5JPH6

Antibodypedia

 EARS2 antibodies

PROTEIN BROWSER
EARS2-001
EARS2-003
EARS2-017
EARS2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EARS2-001
ENSP00000456467
ENST00000563459
Q5JPH6 [Direct mapping]
Probable glutamate--tRNA ligase, mitochondrial
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004818 [glutamate-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006424 [glutamyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
GO:0050561 [glutamate-tRNA(Gln) ligase activity]
GO:0070127 [tRNA aminoacylation for mitochondrial protein translation]
Show all
 523 aa
58.7 kDa 		No 0
EARS2-003
ENSP00000456218
ENST00000563232
Q5JPH6 [Direct mapping]
Probable glutamate--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004818 [glutamate-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006424 [glutamyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
GO:0050561 [glutamate-tRNA(Gln) ligase activity]
GO:0070127 [tRNA aminoacylation for mitochondrial protein translation]
Show all
 534 aa
60 kDa 		No 0
EARS2-017
ENSP00000457107
ENST00000564501
H3BTB7 [Direct mapping]
Probable glutamate--tRNA ligase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004818 [glutamate-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006424 [glutamyl-tRNA aminoacylation]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
 506 aa
56.8 kDa 		No 0
EARS2-201
ENSP00000395196
ENST00000449606
Q5JPH6 [Direct mapping]
Probable glutamate--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004818 [glutamate-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006424 [glutamyl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
GO:0050561 [glutamate-tRNA(Gln) ligase activity]
GO:0070127 [tRNA aminoacylation for mitochondrial protein translation]
Show all
 523 aa
58.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.