Expression of AQP8 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

AQP8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AQP8
Gene description	Aquaporin 8
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, liver cancer, pancreatic cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (colon, pancreas, rectum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in colon, rectum and pancreas.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA046259
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, liver cancer, pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA046259

GENE INFORMATION
Gene name	AQP8
Synonyms
Description	Aquaporin 8 (HGNC Symbol)
Entrez gene summary	Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p12.1
Chromosome location (bp)	25215731 - 25228940
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103375 (version 83.38)
Entrez gene	343
UniProt	O94778 (UniProt - Evidence at transcript level)
neXtProt	NX_O94778
Antibodypedia	AQP8 antibodies

PROTEIN BROWSER

AQP8-001	AQP8-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AQP8-001 ENSP00000219660 ENST00000219660	O94778 [Direct mapping] Aquaporin-8 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006833 [water transport] GO:0009992 [cellular water homeostasis] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0045177 [apical part of cell] GO:0055085 [transmembrane transport] GO:0071320 [cellular response to cAMP] Show all	261 aa 27.4 kDa	No	7
AQP8-002 ENSP00000454457 ENST00000566125	A0A0C4DGL6 [Direct mapping] Aquaporin-8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005623 [cell] GO:0006810 [transport] GO:0009992 [cellular water homeostasis] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	255 aa 26.8 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.