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Most of the malignant cells displayed weak to moderate cytoplasmic positivity. A few cases of ovarian, colorectal, cervical and gastric cancers showed strong cytoplasmic immunoreactivity. several cases of renal and urothelial cancers were negative.
GENE INFORMATION
Gene name
HMOX2 (HGNC Symbol)
Synonyms
HO-2
Description
Heme oxygenase 2 (HGNC Symbol)
Entrez gene summary
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]