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TOX3

GENERAL INFORMATION

Gene name

 TOX3

Gene description

 TOX high mobility group box family member 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AF22, RT4, SCLC-21H)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in several different tissues, including CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA040376
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040376

GENE INFORMATION

Gene name

 TOX3 (HGNC Symbol)

Synonyms

 CAGF9, TNRC9

Description

 TOX high mobility group box family member 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]

Chromosome

 16

Cytoband

 q12.1

Chromosome location (bp)

 52438005 - 52547802

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103460 (version 83.38)

Entrez gene

 27324

UniProt

 O15405 (UniProt - Evidence at protein level)

neXtProt

 NX_O15405

Antibodypedia

 TOX3 antibodies

PROTEIN BROWSER
TOX3-002
TOX3-003
TOX3-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TOX3-002
ENSP00000385705
ENST00000407228
O15405 [Direct mapping]
TOX high mobility group box family member 3
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
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GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0034056 [estrogen response element binding]
GO:0042803 [protein homodimerization activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051219 [phosphoprotein binding]
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 571 aa
63.1 kDa 		No 0
TOX3-003
ENSP00000219746
ENST00000219746
O15405 [Direct mapping]
TOX high mobility group box family member 3
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Show all
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0034056 [estrogen response element binding]
GO:0042803 [protein homodimerization activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051219 [phosphoprotein binding]
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 576 aa
63.3 kDa 		No 0
TOX3-004
ENSP00000457401
ENST00000563091
H3BTZ9 [Direct mapping]
TOX high mobility group box family member 3
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Predicted intracellular proteins
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GO:0006338 [chromatin remodeling]
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 166 aa
17.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.