Tissue expression of RBL2 - Summary - The Human Protein Atlas

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RBL2

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	RBL2
Gene description	Retinoblastoma-like 2
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous nuclear expression.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA019703 , CAB016547
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Cervix, uterine

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	RBL2 (HGNC Symbol)
Synonyms	p130, Rb2
Description	Retinoblastoma-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q12.2
Chromosome location (bp)	53433977 - 53491649
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103479 (version 83.38)
Entrez gene	5934
UniProt	Q08999 (UniProt - Evidence at protein level)
neXtProt	NX_Q08999
Antibodypedia	RBL2 antibodies

PROTEIN BROWSER

RBL2-001	RBL2-002	RBL2-004	RBL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBL2-001 ENSP00000262133 ENST00000262133	Q08999 [Direct mapping] Retinoblastoma-like protein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016568 [chromatin modification] GO:0043550 [regulation of lipid kinase activity] GO:0051726 [regulation of cell cycle] GO:0070062 [extracellular exosome] Show all	1139 aa 128.4 kDa	No	0
RBL2-002 ENSP00000443744 ENST00000544405	F5H837 [Direct mapping] Retinoblastoma-like protein 2 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0051726 [regulation of cell cycle] Show all	639 aa 73.2 kDa	No	0
RBL2-004 ENSP00000462464 ENST00000567964	J3KSF7 [Direct mapping] Retinoblastoma-like protein 2 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005667 [transcription factor complex] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0051726 [regulation of cell cycle] Show all	128 aa 15.3 kDa	No	0
RBL2-201 ENSP00000444685 ENST00000544545	A0A0A0MTM7 [Direct mapping] Retinoblastoma-like protein 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0051726 [regulation of cell cycle] Show all	849 aa 95.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.