Cell atlas - QPRT - The Human Protein Atlas

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QPRT

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	QPRT
Gene description	Quinolinate phosphoribosyltransferase
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (EFO-21)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	QPRT (HGNC Symbol)
Synonyms	QPRTase
Description	Quinolinate phosphoribosyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	29679008 - 29698699
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103485 (version 83.38)
Entrez gene	23475
UniProt	Q15274 (UniProt - Evidence at protein level)
neXtProt	NX_Q15274
Antibodypedia	QPRT antibodies

PROTEIN BROWSER

QPRT-001	QPRT-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
QPRT-001 ENSP00000378782 ENST00000395384	Q15274 [Direct mapping] Nicotinate-nucleotide pyrophosphorylase [carboxylating] Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004514 [nicotinate-nucleotide diphosphorylase (carboxylating) activity] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009435 [NAD biosynthetic process] GO:0016763 [transferase activity, transferring pentosyl groups] GO:0019363 [pyridine nucleotide biosynthetic process] GO:0019674 [NAD metabolic process] GO:0034213 [quinolinate catabolic process] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0051259 [protein oligomerization] GO:0070062 [extracellular exosome] Show all	297 aa 30.8 kDa	Yes	0
QPRT-002 ENSP00000455183 ENST00000562473	H3BP73 [Direct mapping] Nicotinate-nucleotide pyrophosphorylase [carboxylating] Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004514 [nicotinate-nucleotide diphosphorylase (carboxylating) activity] GO:0005737 [cytoplasm] GO:0009435 [NAD biosynthetic process] Show all	149 aa 15.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.