Cell atlas - BCKDK - The Human Protein Atlas

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BCKDK

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	BCKDK
Gene description	Branched chain ketoacid dehydrogenase kinase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA056067
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056067	A-431	Mitochondria
	HPA056067	U-2 OS	Mitochondria
	HPA056067	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	BCKDK
Synonyms
Description	Branched chain ketoacid dehydrogenase kinase (HGNC Symbol)
Entrez gene summary	The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	31106107 - 31112791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103507 (version 83.38)
Entrez gene	10295
UniProt	O14874 (UniProt - Evidence at protein level)
neXtProt	NX_O14874
Antibodypedia	BCKDK antibodies

PROTEIN BROWSER

BCKDK-001	BCKDK-002	BCKDK-003	BCKDK-004	BCKDK-007	BCKDK-008	BCKDK-009	BCKDK-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCKDK-001 ENSP00000219794 ENST00000219794	O14874 [Direct mapping] [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial A0A024QZA9 [Target identity:100%; Query identity:100%] Branched chain ketoacid dehydrogenase kinase, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005947 [mitochondrial alpha-ketoglutarate dehydrogenase complex] GO:0006468 [protein phosphorylation] GO:0009063 [cellular amino acid catabolic process] GO:0009083 [branched-chain amino acid catabolic process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0047323 [[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity] Show all	412 aa 46.4 kDa	No	0
BCKDK-002 ENSP00000378404 ENST00000394950	O14874 [Direct mapping] [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005947 [mitochondrial alpha-ketoglutarate dehydrogenase complex] GO:0006468 [protein phosphorylation] GO:0009063 [cellular amino acid catabolic process] GO:0009083 [branched-chain amino acid catabolic process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0047323 [[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity] Show all	365 aa 41.1 kDa	No	0
BCKDK-003 ENSP00000287507 ENST00000287507	O14874 [Direct mapping] [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005947 [mitochondrial alpha-ketoglutarate dehydrogenase complex] GO:0006468 [protein phosphorylation] GO:0009063 [cellular amino acid catabolic process] GO:0009083 [branched-chain amino acid catabolic process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0047323 [[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity] Show all	335 aa 37.8 kDa	No	0
BCKDK-004 ENSP00000378405 ENST00000394951	O14874 [Direct mapping] [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial A0A024QZA9 [Target identity:100%; Query identity:100%] Branched chain ketoacid dehydrogenase kinase, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005947 [mitochondrial alpha-ketoglutarate dehydrogenase complex] GO:0006468 [protein phosphorylation] GO:0009063 [cellular amino acid catabolic process] GO:0009083 [branched-chain amino acid catabolic process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0047323 [[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity] Show all	412 aa 46.4 kDa	No	0
BCKDK-007 ENSP00000455866 ENST00000561755	H3BQP2 [Direct mapping] [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		60 aa 6.4 kDa	No	0
BCKDK-008 ENSP00000454947 ENST00000567676	H3BNP3 [Direct mapping] [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 9.4 kDa	No	0
BCKDK-009 ENSP00000457821 ENST00000567682	H3BUV3 [Direct mapping] [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 15.3 kDa	No	0
BCKDK-010 ENSP00000457226 ENST00000484226	H3BTL2 [Direct mapping] [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		217 aa 24.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.