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KAT8

GENERAL INFORMATION

Gene name

 KAT8

Gene description

 K(lysine) acetyltransferase 8

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 KAT8 (HGNC Symbol)

Synonyms

 FLJ14040, hMOF, MOF, MYST1, ZC2HC8

Description

 K(lysine) acetyltransferase 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 16

Cytoband

 p11.2

Chromosome location (bp)

 31115754 - 31131393

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103510 (version 83.38)

Entrez gene

 84148

UniProt

 Q9H7Z6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H7Z6

Antibodypedia

 KAT8 antibodies

PROTEIN BROWSER
KAT8-001
KAT8-002
KAT8-004
KAT8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KAT8-001
ENSP00000456933
ENST00000543774
Q9H7Z6 [Direct mapping]
Histone acetyltransferase KAT8
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0010506 [regulation of autophagy]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030099 [myeloid cell differentiation]
GO:0031965 [nuclear membrane]
GO:0035064 [methylated histone binding]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043984 [histone H4-K16 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0046972 [histone acetyltransferase activity (H4-K16 specific)]
GO:0071339 [MLL1 complex]
GO:0072487 [MSL complex]
Show all
 458 aa
52.4 kDa 		No 0
KAT8-002
ENSP00000406037
ENST00000448516
Q9H7Z6 [Direct mapping]
Histone acetyltransferase KAT8
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0000776 [kinetochore]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0010506 [regulation of autophagy]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0019899 [enzyme binding]
GO:0030099 [myeloid cell differentiation]
GO:0031965 [nuclear membrane]
GO:0035064 [methylated histone binding]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043984 [histone H4-K16 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0046972 [histone acetyltransferase activity (H4-K16 specific)]
GO:0071339 [MLL1 complex]
GO:0072487 [MSL complex]
Show all
 467 aa
53.1 kDa 		No 0
KAT8-004
ENSP00000454592
ENST00000537402
H3BMX5 [Direct mapping]
Histone acetyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004402 [histone acetyltransferase activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
Show all
 187 aa
22 kDa 		No 0
KAT8-201
ENSP00000219797
ENST00000219797
Q9H7Z6 [Direct mapping]
Histone acetyltransferase KAT8
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123 [histone acetyltransferase complex]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0010506 [regulation of autophagy]
GO:0016407 [acetyltransferase activity]
GO:0016573 [histone acetylation]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0030099 [myeloid cell differentiation]
GO:0031965 [nuclear membrane]
GO:0035064 [methylated histone binding]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043984 [histone H4-K16 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0046972 [histone acetyltransferase activity (H4-K16 specific)]
GO:0071339 [MLL1 complex]
GO:0072487 [MSL complex]
Show all
 458 aa
52.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.