Expression of IL21R in cancer - Summary - The Human Protein Atlas

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IL21R

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL21R
Gene description	Interleukin 21 receptor
Protein class	Cancer-related genes CD markers Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HDLM-2, Karpas-707, RH-30, RPMI-8226)
HPA (normal tissue):	Tissue enhanced (appendix, lymph node, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA042296
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042296

GENE INFORMATION
Gene name	IL21R (HGNC Symbol)
Synonyms	CD360
Description	Interleukin 21 receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Chromosome	16
Cytoband	p12.1
Chromosome location (bp)	27402162 - 27452042
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103522 (version 83.38)
Entrez gene	50615
UniProt	Q9HBE5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HBE5
Antibodypedia	IL21R antibodies

PROTEIN BROWSER

IL21R-001	IL21R-003	IL21R-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL21R-001 ENSP00000338010 ENST00000337929	Q9HBE5 [Direct mapping] Interleukin-21 receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0001532 [interleukin-21 receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030101 [natural killer cell activation] GO:0038114 [interleukin-21-mediated signaling pathway] Show all	538 aa 59.1 kDa	Yes	1
IL21R-003 ENSP00000379103 ENST00000395754	Q9HBE5 [Direct mapping] Interleukin-21 receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0001532 [interleukin-21 receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030101 [natural killer cell activation] GO:0038114 [interleukin-21-mediated signaling pathway] Show all	538 aa 59.1 kDa	Yes	1
IL21R-006 ENSP00000456707 ENST00000564089	Q9HBE5 [Direct mapping] Interleukin-21 receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0001532 [interleukin-21 receptor activity] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030101 [natural killer cell activation] GO:0038114 [interleukin-21-mediated signaling pathway] Show all	538 aa 59.1 kDa	Yes	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.