Expression of TMC5 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TMC5
Gene description	Transmembrane channel-like 5
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (CAPAN-2)
HPA (normal tissue):	Tissue enhanced (small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in a few tissues including the intestinal tract. Additional cytoplasmic positivity in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA040810 , HPA042037
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA040810	HPA042037

GENE INFORMATION
Gene name	TMC5 (HGNC Symbol)
Synonyms	FLJ13593
Description	Transmembrane channel-like 5 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	19410496 - 19499113
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103534 (version 83.38)
Entrez gene	79838
UniProt	Q6UXY8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6UXY8
Antibodypedia	TMC5 antibodies

PROTEIN BROWSER

TMC5-001	TMC5-002	TMC5-004	TMC5-005	TMC5-006	TMC5-007	TMC5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMC5-001 ENSP00000370822 ENST00000381414	Q6UXY8 [Direct mapping] Transmembrane channel-like protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	948 aa 108.1 kDa	No	8
TMC5-002 ENSP00000219821 ENST00000219821	Q6UXY8 [Direct mapping] Transmembrane channel-like protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	760 aa 87.8 kDa	No	9
TMC5-004 ENSP00000456148 ENST00000561503	Q6UXY8 [Direct mapping] Transmembrane channel-like protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	647 aa 75.5 kDa	No	9
TMC5-005 ENSP00000454710 ENST00000564959	H3BN68 [Direct mapping] Transmembrane channel-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	689 aa 80.1 kDa	No	9
TMC5-006 ENSP00000446274 ENST00000542583	Q6UXY8 [Direct mapping] Transmembrane channel-like protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1006 aa 114.8 kDa	No	9
TMC5-007 ENSP00000441227 ENST00000541464	F5GYU8 [Direct mapping] Transmembrane channel-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	954 aa 108.9 kDa	No	8
TMC5-201 ENSP00000379531 ENST00000396229	Q6UXY8 [Direct mapping] Transmembrane channel-like protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1006 aa 114.8 kDa	No	9