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AQP9

GENERAL INFORMATION

Gene name

 AQP9

Gene description

 Aquaporin 9

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (U-87 MG)
HPA (normal tissue):Tissue enhanced (appendix, liver)

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 AQP9 (HGNC Symbol)

Synonyms

 HsT17287, SSC1

Description

 Aquaporin 9 (HGNC Symbol)

Entrez gene summary

 The aquaporins are a family of water-selective membrane channels. The protein encoded by this gene allows passage of a wide variety of noncharged solutes. It stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q21.3

Chromosome location (bp)

 58138169 - 58185911

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000103569 (version 83.38)

Entrez gene

 366

UniProt

 O43315 (UniProt - Evidence at transcript level)

neXtProt

 NX_O43315

Antibodypedia

 AQP9 antibodies

PROTEIN BROWSER
AQP9-001
AQP9-002
AQP9-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AQP9-001
ENSP00000219919
ENST00000219919
O43315 [Direct mapping]
Aquaporin-9
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005275 [amine transmembrane transporter activity]
GO:0005345 [purine nucleobase transmembrane transporter activity]
GO:0005350 [pyrimidine nucleobase transmembrane transporter activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0006863 [purine nucleobase transport]
GO:0006955 [immune response]
GO:0006970 [response to osmotic stress]
GO:0007588 [excretion]
GO:0008152 [metabolic process]
GO:0009992 [cellular water homeostasis]
GO:0010033 [response to organic substance]
GO:0015166 [polyol transmembrane transporter activity]
GO:0015204 [urea transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015288 [porin activity]
GO:0015722 [canalicular bile acid transport]
GO:0015791 [polyol transport]
GO:0015793 [glycerol transport]
GO:0015837 [amine transport]
GO:0015855 [pyrimidine nucleobase transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0030104 [water homeostasis]
GO:0034220 [ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046689 [response to mercury ion]
GO:0046942 [carboxylic acid transport]
GO:0046943 [carboxylic acid transmembrane transporter activity]
GO:0055085 [transmembrane transport]
GO:0071320 [cellular response to cAMP]
GO:0071918 [urea transmembrane transport]
GO:0072531 [pyrimidine-containing compound transmembrane transport]
Show all
 295 aa
31.4 kDa 		No 6
AQP9-002
ENSP00000452673
ENST00000558772
H0YK62 [Direct mapping]
Aquaporin-9
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005623 [cell]
GO:0006810 [transport]
GO:0009992 [cellular water homeostasis]
GO:0015204 [urea transmembrane transporter activity]
GO:0015254 [glycerol channel activity]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0071918 [urea transmembrane transport]
Show all
 230 aa
24.5 kDa 		No 5
AQP9-201
ENSP00000441390
ENST00000536493
O43315 [Direct mapping]
Aquaporin-9
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0005275 [amine transmembrane transporter activity]
GO:0005345 [purine nucleobase transmembrane transporter activity]
GO:0005350 [pyrimidine nucleobase transmembrane transporter activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006833 [water transport]
GO:0006863 [purine nucleobase transport]
GO:0006955 [immune response]
GO:0006970 [response to osmotic stress]
GO:0007588 [excretion]
GO:0008152 [metabolic process]
GO:0009992 [cellular water homeostasis]
GO:0010033 [response to organic substance]
GO:0015166 [polyol transmembrane transporter activity]
GO:0015204 [urea transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015288 [porin activity]
GO:0015791 [polyol transport]
GO:0015793 [glycerol transport]
GO:0015837 [amine transport]
GO:0015855 [pyrimidine nucleobase transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030104 [water homeostasis]
GO:0034220 [ion transmembrane transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046689 [response to mercury ion]
GO:0046942 [carboxylic acid transport]
GO:0046943 [carboxylic acid transmembrane transporter activity]
GO:0055085 [transmembrane transport]
GO:0071320 [cellular response to cAMP]
GO:0071918 [urea transmembrane transport]
GO:0072531 [pyrimidine-containing compound transmembrane transport]
Show all
 295 aa
31.4 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.