Expression of LACTB in cancer - Summary - The Human Protein Atlas

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LACTB

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LACTB
Gene description	Lactamase, beta
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA036361 , HPA036362
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036361	HPA036362

GENE INFORMATION
Gene name	LACTB (HGNC Symbol)
Synonyms	FLJ14902, MRPL56
Description	Lactamase, beta (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]
Chromosome	15
Cytoband	q22.2
Chromosome location (bp)	63121800 - 63142061
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103642 (version 83.38)
Entrez gene	114294
UniProt	P83111 (UniProt - Evidence at protein level)
neXtProt	NX_P83111
Antibodypedia	LACTB antibodies

PROTEIN BROWSER

LACTB-001	LACTB-002	LACTB-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LACTB-001 ENSP00000261893 ENST00000261893	P83111 [Direct mapping] Serine beta-lactamase-like protein LACTB, mitochondrial Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	547 aa 60.7 kDa	Yes	0
LACTB-002 ENSP00000392956 ENST00000413507	P83111 [Direct mapping] Serine beta-lactamase-like protein LACTB, mitochondrial Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	373 aa 41.2 kDa	Yes	0
LACTB-003 ENSP00000454085 ENST00000557972	H0YNN5 [Direct mapping] Serine beta-lactamase-like protein LACTB, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 14.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.