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MTFMT

GENERAL INFORMATION

Gene name

 MTFMT

Gene description

 Mitochondrial methionyl-tRNA formyltransferase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA040710
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040710

GENE INFORMATION

Gene name

 MTFMT (HGNC Symbol)

Synonyms

 FMT1

Description

 Mitochondrial methionyl-tRNA formyltransferase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011]

Chromosome

 15

Cytoband

 q22.31

Chromosome location (bp)

 65001512 - 65029639

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103707 (version 83.38)

Entrez gene

 123263

UniProt

 Q96DP5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96DP5

Antibodypedia

 MTFMT antibodies

PROTEIN BROWSER
MTFMT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTFMT-001
ENSP00000220058
ENST00000220058
Q96DP5 [Direct mapping]
Methionyl-tRNA formyltransferase, mitochondrial
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004479 [methionyl-tRNA formyltransferase activity]
GO:0005739 [mitochondrion]
GO:0006996 [organelle organization]
GO:0009058 [biosynthetic process]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032543 [mitochondrial translation]
GO:0070124 [mitochondrial translational initiation]
GO:0071951 [conversion of methionyl-tRNA to N-formyl-methionyl-tRNA]
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 389 aa
43.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.