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RAB11A

GENERAL INFORMATION

Gene name

 RAB11A

Gene description

 RAB11A, member RAS oncogene family

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA060686 , CAB013097
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA060686
CAB013097

GENE INFORMATION

Gene name

 RAB11A (HGNC Symbol)

Synonyms

 YL8

Description

 RAB11A, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Chromosome

 15

Cytoband

 q22.31

Chromosome location (bp)

 65726054 - 65891991

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000103769 (version 83.38)

Entrez gene

 8766

UniProt

 P62491 (UniProt - Evidence at protein level)

neXtProt

 NX_P62491

Antibodypedia

 RAB11A antibodies

PROTEIN BROWSER
RAB11A-001
RAB11A-002
RAB11A-003
RAB11A-004
RAB11A-005
RAB11A-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB11A-001
ENSP00000261890
ENST00000261890
P62491 [Direct mapping]
Ras-related protein Rab-11A
A0A024R5Z8 [Target identity:100%; Query identity:100%]
RAB11A, member RAS oncogene family, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0003091 [renal water homeostasis]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005771 [multivesicular body]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005813 [centrosome]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006833 [water transport]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0006996 [organelle organization]
GO:0007080 [mitotic metaphase plate congression]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010796 [regulation of multivesicular body size]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0030133 [transport vesicle]
GO:0030424 [axon]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030953 [astral microtubule organization]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031489 [myosin V binding]
GO:0031982 [vesicle]
GO:0032154 [cleavage furrow]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0036258 [multivesicular body assembly]
GO:0043234 [protein complex]
GO:0045335 [phagocytic vesicle]
GO:0045773 [positive regulation of axon extension]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048227 [plasma membrane to endosome transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051223 [regulation of protein transport]
GO:0051650 [establishment of vesicle localization]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0055085 [transmembrane transport]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0070062 [extracellular exosome]
GO:0072594 [establishment of protein localization to organelle]
GO:0072659 [protein localization to plasma membrane]
GO:0090150 [establishment of protein localization to membrane]
GO:0090307 [mitotic spindle assembly]
GO:1990182 [exosomal secretion]
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 216 aa
24.4 kDa 		No 0
RAB11A-002
ENSP00000455567
ENST00000564910
B4DQU5 [Direct mapping]
Ras-related protein Rab-11A; cDNA FLJ57160, highly similar to Ras-related protein Rab-11A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
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 146 aa
16.5 kDa 		No 0
RAB11A-003
ENSP00000456420
ENST00000569896
P62491 [Direct mapping]
Ras-related protein Rab-11A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0000922 [spindle pole]
GO:0003091 [renal water homeostasis]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005771 [multivesicular body]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005813 [centrosome]
GO:0005828 [kinetochore microtubule]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006833 [water transport]
GO:0006886 [intracellular protein transport]
GO:0006996 [organelle organization]
GO:0007080 [mitotic metaphase plate congression]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010796 [regulation of multivesicular body size]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019905 [syntaxin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030670 [phagocytic vesicle membrane]
GO:0030953 [astral microtubule organization]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031489 [myosin V binding]
GO:0031982 [vesicle]
GO:0032154 [cleavage furrow]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
GO:0036258 [multivesicular body assembly]
GO:0043234 [protein complex]
GO:0045335 [phagocytic vesicle]
GO:0048227 [plasma membrane to endosome transport]
GO:0051650 [establishment of vesicle localization]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0055085 [transmembrane transport]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0070062 [extracellular exosome]
GO:0072594 [establishment of protein localization to organelle]
GO:0072659 [protein localization to plasma membrane]
GO:0090150 [establishment of protein localization to membrane]
GO:0090307 [mitotic spindle assembly]
GO:1990182 [exosomal secretion]
Show all
 155 aa
17.7 kDa 		No 0
RAB11A-004
ENSP00000456638
ENST00000565075
H3BSC1 [Direct mapping]
Ras-related protein Rab-11A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 198 aa
22.5 kDa 		No 0
RAB11A-005
ENSP00000454673
ENST00000567671
H3BN38 [Direct mapping]
Ras-related protein Rab-11A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
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 82 aa
9.2 kDa 		No 0
RAB11A-009
ENSP00000454381
ENST00000566233
H3BMH2 [Direct mapping]
Ras-related protein Rab-11A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005623 [cell]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032402 [melanosome transport]
GO:0032482 [Rab protein signal transduction]
Show all
 155 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.