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SGK3

GENERAL INFORMATION

Gene name

 SGK3

Gene description

 Serum/glucocorticoid regulated kinase family, member 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 1 antibody.
HPA027146
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable), cervical cancer (favourable) and pancreatic cancer (favourable).
Breast cancer p<0.001
Cervical cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027146

GENE INFORMATION

Gene name

 SGK3 (HGNC Symbol)

Synonyms

 SGK2, SGKL

Description

 Serum/glucocorticoid regulated kinase family, member 3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q13.1

Chromosome location (bp)

 66712418 - 66862022

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104205 (version 83.38)

Entrez gene

 23678

UniProt

 Q96BR1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96BR1

Antibodypedia

 SGK3 antibodies

PROTEIN BROWSER
SGK3-003
SGK3-004
SGK3-005
SGK3-006
SGK3-007
SGK3-013
SGK3-014
SGK3-015
SGK3-016
SGK3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SGK3-003
ENSP00000430256
ENST00000522398
Q96BR1 [Direct mapping]
Serine/threonine-protein kinase Sgk3
A0A024R807 [Target identity:100%; Query identity:100%]
Serum/glucocorticoid regulated kinase family, member 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006950 [response to stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
Show all
 496 aa
57.1 kDa 		No 0
SGK3-004
ENSP00000430691
ENST00000520976
Q96BR1 [Direct mapping]
Serine/threonine-protein kinase Sgk3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006950 [response to stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
Show all
 464 aa
53.3 kDa 		No 0
SGK3-005
ENSP00000430463
ENST00000521198
Q96BR1 [Direct mapping]
Serine/threonine-protein kinase Sgk3
A0A024R807 [Target identity:100%; Query identity:100%]
Serum/glucocorticoid regulated kinase family, member 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006950 [response to stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
Show all
 496 aa
57.1 kDa 		No 0
SGK3-006
ENSP00000430475
ENST00000521960
E5RJV7 [Direct mapping]
Serine/threonine-protein kinase Sgk3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035091 [phosphatidylinositol binding]
Show all
 109 aa
12.4 kDa 		No 0
SGK3-007
ENSP00000428972
ENST00000518388
E5RK28 [Direct mapping]
Serine/threonine-protein kinase Sgk3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035091 [phosphatidylinositol binding]
Show all
 128 aa
15.3 kDa 		No 0
SGK3-013
ENSP00000331816
ENST00000345714
Q96BR1 [Direct mapping]
Serine/threonine-protein kinase Sgk3
A0A024R807 [Target identity:100%; Query identity:100%]
Serum/glucocorticoid regulated kinase family, member 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006950 [response to stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
Show all
 496 aa
57.1 kDa 		No 0
SGK3-014
ENSP00000429606
ENST00000522629
E5RHX2 [Direct mapping]
Serine/threonine-protein kinase Sgk3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035091 [phosphatidylinositol binding]
Show all
 149 aa
17.7 kDa 		No 0
SGK3-015
ENSP00000429565
ENST00000521152
E5RHY6 [Direct mapping]
Serine/threonine-protein kinase Sgk3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0035091 [phosphatidylinositol binding]
Show all
 166 aa
19.7 kDa 		No 0
SGK3-016
ENSP00000428529
ENST00000519396
E5RHR8 [Direct mapping]
Serine/threonine-protein kinase Sgk3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 126 aa
14.4 kDa 		No 0
SGK3-201
ENSP00000379842
ENST00000396596
Q96BR1 [Direct mapping]
Serine/threonine-protein kinase Sgk3
A0A024R807 [Target identity:100%; Query identity:100%]
Serum/glucocorticoid regulated kinase family, member 3, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005246 [calcium channel regulator activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006883 [cellular sodium ion homeostasis]
GO:0006950 [response to stress]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0017080 [sodium channel regulator activity]
GO:0017081 [chloride channel regulator activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030334 [regulation of cell migration]
GO:0032411 [positive regulation of transporter activity]
GO:0034220 [ion transmembrane transport]
GO:0035091 [phosphatidylinositol binding]
GO:0035556 [intracellular signal transduction]
GO:0042127 [regulation of cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
Show all
 496 aa
57.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.