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PDGFRL

GENERAL INFORMATION

Gene name

 PDGFRL

Gene description

 Platelet-derived growth factor receptor-like

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (AN3-CA, BJ hTERT+)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PDGFRL (HGNC Symbol)

Synonyms

 PRLTS

Description

 Platelet-derived growth factor receptor-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p22

Chromosome location (bp)

 17576433 - 17644071

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104213 (version 83.38)

Entrez gene

 5157

UniProt

 Q15198 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15198

Antibodypedia

 PDGFRL antibodies

PROTEIN BROWSER
PDGFRL-001
PDGFRL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDGFRL-001
ENSP00000251630
ENST00000251630
Q15198 [Direct mapping]
Platelet-derived growth factor receptor-like protein
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0004992 [platelet activating factor receptor activity]
GO:0005019 [platelet-derived growth factor beta-receptor activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005576 [extracellular region]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008150 [biological_process]
GO:0035791 [platelet-derived growth factor receptor-beta signaling pathway]
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 375 aa
41.9 kDa 		Yes 0
PDGFRL-201
ENSP00000444211
ENST00000541323
Q15198 [Direct mapping]
Platelet-derived growth factor receptor-like protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0004992 [platelet activating factor receptor activity]
GO:0005019 [platelet-derived growth factor beta-receptor activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005576 [extracellular region]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008150 [biological_process]
GO:0035791 [platelet-derived growth factor receptor-beta signaling pathway]
Show all
 375 aa
41.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.