Expression of BRF2 in cancer - Summary - The Human Protein Atlas

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BRF2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BRF2
Gene description	BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA023378 , CAB019269
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023378	CAB019269

GENE INFORMATION
Gene name	BRF2 (HGNC Symbol)
Synonyms	BRFU, FLJ11052, TFIIIB50
Description	BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit (HGNC Symbol)
Entrez gene summary	This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	37843268 - 37849904
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104221 (version 83.38)
Entrez gene	55290
UniProt	Q9HAW0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAW0
Antibodypedia	BRF2 antibodies

PROTEIN BROWSER

BRF2-001	BRF2-003	BRF2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRF2-001 ENSP00000220659 ENST00000220659	Q9HAW0 [Direct mapping] Transcription factor IIIB 50 kDa subunit Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005654 [nucleoplasm] GO:0006352 [DNA-templated transcription, initiation] GO:0006355 [regulation of transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] Show all	419 aa 46.5 kDa	No	0
BRF2-003 ENSP00000430193 ENST00000521170	E5RGF6 [Direct mapping] Transcription factor IIIB 50 kDa subunit Show all	Predicted intracellular proteins Show all	GO:0006352 [DNA-templated transcription, initiation] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] Show all	72 aa 7.9 kDa	No	0
BRF2-005 ENSP00000430107 ENST00000520601	E5RGX1 [Direct mapping] Transcription factor IIIB 50 kDa subunit Show all	Predicted intracellular proteins Show all	GO:0006352 [DNA-templated transcription, initiation] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] Show all	202 aa 22.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.