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CA2

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GENERAL INFORMATION

Gene name

 CA2

Gene description

 Carbonic anhydrase II

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (HEK 293, THP-1, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HEK 293, THP-1, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CA2 (HGNC Symbol)

Synonyms

 CA-II, CAII, Car2

Description

 Carbonic anhydrase II (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Chromosome

 8

Cytoband

 q21.2

Chromosome location (bp)

 85463852 - 85481493

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104267 (version 83.38)

Entrez gene

 760

UniProt

 P00918 (UniProt - Evidence at protein level)

neXtProt

 NX_P00918

Antibodypedia

 CA2 antibodies

PROTEIN BROWSER
CA2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CA2-001
ENSP00000285379
ENST00000285379
P00918 [Direct mapping]
Carbonic anhydrase 2
V9HW21 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 76
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0002009 [morphogenesis of an epithelium]
GO:0004064 [arylesterase activity]
GO:0004089 [carbonate dehydratase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0009268 [response to pH]
GO:0010033 [response to organic substance]
GO:0010043 [response to zinc ion]
GO:0015701 [bicarbonate transport]
GO:0016323 [basolateral plasma membrane]
GO:0030424 [axon]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0032849 [positive regulation of cellular pH reduction]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0043209 [myelin sheath]
GO:0043627 [response to estrogen]
GO:0044070 [regulation of anion transport]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0046903 [secretion]
GO:0048545 [response to steroid hormone]
GO:0051453 [regulation of intracellular pH]
GO:0070062 [extracellular exosome]
GO:0071498 [cellular response to fluid shear stress]
GO:2001150 [positive regulation of dipeptide transmembrane transport]
GO:2001225 [regulation of chloride transport]
Show all
 260 aa
29.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.