Fields »
ABOUT
HELP
BLOG
IMPAD1

GENERAL INFORMATION

Gene name

 IMPAD1

Gene description

 Inositol monophosphatase domain containing 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA009411
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IMPAD1 (HGNC Symbol)

Synonyms

 FLJ20421, gPAPP, IMPA3

Description

 Inositol monophosphatase domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, Dec 2011]

Chromosome

 8

Cytoband

 q12.1

Chromosome location (bp)

 56957933 - 56993844

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104331 (version 83.38)

Entrez gene

 54928

UniProt

 Q9NX62 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NX62

Antibodypedia

 IMPAD1 antibodies

PROTEIN BROWSER
IMPAD1-001
IMPAD1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IMPAD1-001
ENSP00000262644
ENST00000262644
Q9NX62 [Direct mapping]
Inositol monophosphatase 3
A0A024R7W0 [Target identity:100%; Query identity:100%]
Inositol monophosphatase domain containing 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001501 [skeletal system development]
GO:0001958 [endochondral ossification]
GO:0002063 [chondrocyte development]
GO:0005794 [Golgi apparatus]
GO:0006021 [inositol biosynthetic process]
GO:0008254 [3'-nucleotidase activity]
GO:0008441 [3'(2'),5'-bisphosphate nucleotidase activity]
GO:0008934 [inositol monophosphate 1-phosphatase activity]
GO:0009791 [post-embryonic development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0042733 [embryonic digit morphogenesis]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0052832 [inositol monophosphate 3-phosphatase activity]
GO:0052833 [inositol monophosphate 4-phosphatase activity]
Show all
 359 aa
38.7 kDa 		No 1
IMPAD1-002
ENSP00000430185
ENST00000517461
H0YBS3 [Direct mapping]
Inositol monophosphatase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046854 [phosphatidylinositol phosphorylation]
Show all
 82 aa
9.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.