Expression of LAPTM4B in cancer - Summary - The Human Protein Atlas

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LAPTM4B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LAPTM4B
Gene description	Lysosomal protein transmembrane 4 beta
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. CAB020782
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), breast cancer (unfavourable) and head and neck cancer (unfavourable).
Liver cancer p<0.001 Breast cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB020782

GENE INFORMATION
Gene name	LAPTM4B (HGNC Symbol)
Synonyms	LC27
Description	Lysosomal protein transmembrane 4 beta (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q22.1
Chromosome location (bp)	97775057 - 97853013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104341 (version 83.38)
Entrez gene	55353
UniProt	Q86VI4 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VI4
Antibodypedia	LAPTM4B antibodies

PROTEIN BROWSER

LAPTM4B-001	LAPTM4B-002	LAPTM4B-003	LAPTM4B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAPTM4B-001 ENSP00000402301 ENST00000445593	Q86VI4 [Direct mapping] Lysosomal-associated transmembrane protein 4B Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0006810 [transport] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	317 aa 35.1 kDa	No	4
LAPTM4B-002 ENSP00000428409 ENST00000521545	Q86VI4 [Direct mapping] Lysosomal-associated transmembrane protein 4B Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0006810 [transport] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	226 aa 25.4 kDa	No	4
LAPTM4B-003 ENSP00000429868 ENST00000517924	H0YBN1 [Direct mapping] Lysosomal-associated transmembrane protein 4B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	152 aa 17.3 kDa	No	3
LAPTM4B-201 ENSP00000482533 ENST00000619747	Q86VI4 [Direct mapping] Lysosomal-associated transmembrane protein 4B Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0006810 [transport] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	317 aa 35.1 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.