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IKBKB

GENERAL INFORMATION

Gene name

 IKBKB

Gene description

 Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Protein class

 Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA001249 , CAB004447
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001249
CAB004447

GENE INFORMATION

Gene name

 IKBKB (HGNC Symbol)

Synonyms

 IKK-beta, IKK2, IKKB, NFKBIKB

Description

 Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 42271302 - 42332653

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104365 (version 83.38)

Entrez gene

 3551

UniProt

 O14920 (UniProt - Evidence at protein level)

neXtProt

 NX_O14920

Antibodypedia

 IKBKB antibodies

PROTEIN BROWSER
IKBKB-002
IKBKB-004
IKBKB-006
IKBKB-019
IKBKB-022
IKBKB-201
IKBKB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IKBKB-002
ENSP00000430684
ENST00000520810
O14920 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001782 [B cell homeostasis]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003009 [skeletal muscle contraction]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007252 [I-kappaB phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008384 [IkappaB kinase activity]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0009636 [response to toxic substance]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010765 [positive regulation of sodium ion transport]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010976 [positive regulation of neuron projection development]
GO:0019901 [protein kinase binding]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0031175 [neuron projection development]
GO:0032481 [positive regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity]
GO:0035631 [CD40 receptor complex]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042325 [regulation of phosphorylation]
GO:0042493 [response to drug]
GO:0042501 [serine phosphorylation of STAT protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070542 [response to fatty acid]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097110 [scaffold protein binding]
GO:1901216 [positive regulation of neuron death]
GO:1903140 [regulation of establishment of endothelial barrier]
GO:1903347 [negative regulation of bicellular tight junction assembly]
GO:2001259 [positive regulation of cation channel activity]
Show all
 756 aa
86.6 kDa 		No 0
IKBKB-004
ENSP00000430483
ENST00000519735
O14920 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007252 [I-kappaB phosphorylation]
GO:0008384 [IkappaB kinase activity]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity]
GO:0035631 [CD40 receptor complex]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042325 [regulation of phosphorylation]
GO:0042501 [serine phosphorylation of STAT protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097110 [scaffold protein binding]
GO:1903140 [regulation of establishment of endothelial barrier]
GO:1903347 [negative regulation of bicellular tight junction assembly]
Show all
 256 aa
29.2 kDa 		No 0
IKBKB-006
ENSP00000430868
ENST00000520835
O14920 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007252 [I-kappaB phosphorylation]
GO:0008384 [IkappaB kinase activity]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity]
GO:0035631 [CD40 receptor complex]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042325 [regulation of phosphorylation]
GO:0042501 [serine phosphorylation of STAT protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097110 [scaffold protein binding]
GO:1903140 [regulation of establishment of endothelial barrier]
GO:1903347 [negative regulation of bicellular tight junction assembly]
Show all
 754 aa
85.9 kDa 		No 0
IKBKB-019
ENSP00000427978
ENST00000518983
E5RFT3 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit beta
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.3 kDa 		No 0
IKBKB-022
ENSP00000428892
ENST00000522147
E5RFG5 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit beta
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 109 aa
12.1 kDa 		No 0
IKBKB-201
ENSP00000404920
ENST00000416505
O14920 [Direct mapping]
Inhibitor of nuclear factor kappa-B kinase subunit beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007252 [I-kappaB phosphorylation]
GO:0008384 [IkappaB kinase activity]
GO:0008385 [IkappaB kinase complex]
GO:0009615 [response to virus]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0032481 [positive regulation of type I interferon production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity]
GO:0035631 [CD40 receptor complex]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042325 [regulation of phosphorylation]
GO:0042501 [serine phosphorylation of STAT protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097110 [scaffold protein binding]
GO:1903140 [regulation of establishment of endothelial barrier]
GO:1903347 [negative regulation of bicellular tight junction assembly]
Show all
 697 aa
79.5 kDa 		No 0
IKBKB-202
ENSP00000486961
ENST00000629753
G3V105 [Direct mapping]
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, isoform CRA_b; Inhibitor of nuclear factor kappa-B kinase subunit beta
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
 562 aa
63.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.