Expression of EMC2 in cancer - Summary - The Human Protein Atlas

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EMC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	EMC2
Gene description	ER membrane protein complex subunit 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA022838
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022838

GENE INFORMATION
Gene name	EMC2 (HGNC Symbol)
Synonyms	KIAA0103, TTC35
Description	ER membrane protein complex subunit 2 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q23.1
Chromosome location (bp)	108443601 - 108486918
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104412 (version 83.38)
Entrez gene	9694
UniProt	Q15006 (UniProt - Evidence at protein level)
neXtProt	NX_Q15006
Antibodypedia	EMC2 antibodies

PROTEIN BROWSER

EMC2-001	EMC2-003	EMC2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EMC2-001 ENSP00000220853 ENST00000220853	Q15006 [Direct mapping] ER membrane protein complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0072546 [ER membrane protein complex] Show all	297 aa 34.8 kDa	No	0
EMC2-003 ENSP00000430122 ENST00000524143	E5RGJ2 [Direct mapping] ER membrane protein complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 13.5 kDa	No	0
EMC2-007 ENSP00000428040 ENST00000519642	H0YAS9 [Direct mapping] ER membrane protein complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	135 aa 15.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.