Expression of ESRP1 in cancer - Summary - The Human Protein Atlas

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ESRP1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ESRP1
Gene description	Epithelial splicing regulatory protein 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431, BEWO, CAPAN-2, hTCEpi, T-47d)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly expressed in the nucleus in most epithelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA023719 , HPA023720
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (unfavourable), endometrial cancer (unfavourable) and breast cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Endometrial cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023719	HPA023720

GENE INFORMATION
Gene name	ESRP1 (HGNC Symbol)
Synonyms	FLJ20171, RBM35A
Description	Epithelial splicing regulatory protein 1 (HGNC Symbol)
Entrez gene summary	ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
Chromosome	8
Cytoband	q22.1
Chromosome location (bp)	94641074 - 94707466
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104413 (version 83.38)
Entrez gene	54845
UniProt	Q6NXG1 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NXG1
Antibodypedia	ESRP1 antibodies

PROTEIN BROWSER

ESRP1-001	ESRP1-002	ESRP1-003	ESRP1-004	ESRP1-005	ESRP1-006	ESRP1-008	ESRP1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ESRP1-001 ENSP00000405738 ENST00000433389	Q6NXG1 [Direct mapping] Epithelial splicing regulatory protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] Show all	681 aa 75.6 kDa	Yes	0
ESRP1-002 ENSP00000351168 ENST00000358397	Q6NXG1 [Direct mapping] Epithelial splicing regulatory protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] Show all	677 aa 75.1 kDa	Yes	0
ESRP1-003 ENSP00000407349 ENST00000423620	Q6NXG1 [Direct mapping] Epithelial splicing regulatory protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] Show all	659 aa 73.1 kDa	Yes	0
ESRP1-004 ENSP00000402766 ENST00000454170	Q6NXG1 [Direct mapping] Epithelial splicing regulatory protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003729 [mRNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0043484 [regulation of RNA splicing] Show all	608 aa 67.7 kDa	Yes	0
ESRP1-005 ENSP00000430118 ENST00000519505	H0YBR2 [Direct mapping] Epithelial-splicing regulatory protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	502 aa 56 kDa	No	0
ESRP1-006 ENSP00000429125 ENST00000517610	H0YBB3 [Direct mapping] Epithelial-splicing regulatory protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	522 aa 57.9 kDa	No	0
ESRP1-008 ENSP00000430207 ENST00000520385	E5RGE9 [Direct mapping] Epithelial-splicing regulatory protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		24 aa 2.8 kDa	No	0
ESRP1-009 ENSP00000428490 ENST00000522756	E5RI26 [Direct mapping] Epithelial-splicing regulatory protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	94 aa 10.5 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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