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IL7

GENERAL INFORMATION

Gene name

 IL7

Gene description

 Interleukin 7

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in several tissues, including lymph node and small intestine.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA019590
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION

Gene name

 IL7 (HGNC Symbol)

Synonyms

 IL-7

Description

 Interleukin 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

Chromosome

 8

Cytoband

 q21.13

Chromosome location (bp)

 78675743 - 78805523

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104432 (version 83.38)

Entrez gene

 3574

UniProt

 P13232 (UniProt - Evidence at protein level)

neXtProt

 NX_P13232

Antibodypedia

 IL7 antibodies

PROTEIN BROWSER
IL7-001
IL7-004
IL7-201
IL7-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL7-001
ENSP00000263851
ENST00000263851
P13232 [Direct mapping]
Interleukin-7
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0002360 [T cell lineage commitment]
GO:0005125 [cytokine activity]
GO:0005126 [cytokine receptor binding]
GO:0005139 [interleukin-7 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0006959 [humoral immune response]
GO:0007267 [cell-cell signaling]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0010468 [regulation of gene expression]
GO:0030890 [positive regulation of B cell proliferation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0045453 [bone resorption]
GO:0045582 [positive regulation of T cell differentiation]
GO:0046622 [positive regulation of organ growth]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 177 aa
20.2 kDa 		Yes 0
IL7-004
ENSP00000427750
ENST00000520269
P13232 [Direct mapping]
Interleukin-7
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0002360 [T cell lineage commitment]
GO:0005125 [cytokine activity]
GO:0005126 [cytokine receptor binding]
GO:0005139 [interleukin-7 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0006959 [humoral immune response]
GO:0007267 [cell-cell signaling]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0030890 [positive regulation of B cell proliferation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045453 [bone resorption]
GO:0045582 [positive regulation of T cell differentiation]
Show all
 133 aa
15.2 kDa 		Yes 0
IL7-201
ENSP00000368408
ENST00000379113
Q5FBX5 [Direct mapping]
IL7 nirs variant 1; Interleukin-7
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0002360 [T cell lineage commitment]
GO:0005125 [cytokine activity]
GO:0005126 [cytokine receptor binding]
GO:0005139 [interleukin-7 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0008083 [growth factor activity]
GO:0030890 [positive regulation of B cell proliferation]
GO:0045582 [positive regulation of T cell differentiation]
Show all
 115 aa
13.4 kDa 		Yes 0
IL7-202
ENSP00000438922
ENST00000541183
A0A0A0MTG5 [Direct mapping]
Interleukin-7
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0002360 [T cell lineage commitment]
GO:0005125 [cytokine activity]
GO:0005126 [cytokine receptor binding]
GO:0005139 [interleukin-7 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006955 [immune response]
GO:0008083 [growth factor activity]
GO:0030890 [positive regulation of B cell proliferation]
GO:0045453 [bone resorption]
GO:0045582 [positive regulation of T cell differentiation]
Show all
 159 aa
18.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.