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STMN2

GENERAL INFORMATION

Gene name

 STMN2

Gene description

 Stathmin 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, pancreatic cancer)
HPA (cell line):Cell line enriched (SH-SY5Y)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, pancreatic cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 STMN2 (HGNC Symbol)

Synonyms

 SCG10, SCGN10

Description

 Stathmin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

Chromosome

 8

Cytoband

 q21.13

Chromosome location (bp)

 79610814 - 79666175

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104435 (version 83.38)

Entrez gene

 11075

UniProt

 Q93045 (UniProt - Evidence at protein level)

neXtProt

 NX_Q93045

Antibodypedia

 STMN2 antibodies

PROTEIN BROWSER
STMN2-001
STMN2-007
STMN2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STMN2-001
ENSP00000220876
ENST00000220876
Q93045 [Direct mapping]
Stathmin-2
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0007019 [microtubule depolymerization]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031175 [neuron projection development]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:1990090 [cellular response to nerve growth factor stimulus]
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 179 aa
20.8 kDa 		No 0
STMN2-007
ENSP00000430102
ENST00000518491
E5RGX5 [Direct mapping]
Stathmin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007019 [microtubule depolymerization]
GO:0015631 [tubulin binding]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031175 [neuron projection development]
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 168 aa
19.6 kDa 		No 0
STMN2-008
ENSP00000429243
ENST00000518111
Q93045 [Direct mapping]
Stathmin-2
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0007019 [microtubule depolymerization]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031175 [neuron projection development]
GO:0031982 [vesicle]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
 187 aa
21.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.