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SPAG1

GENERAL INFORMATION

Gene name

 SPAG1

Gene description

 Sperm associated antigen 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Mixed
FANTOM5:Tissue enhanced (pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in seminiferous ducts and in ciliated cells of the respiratory tract, fallopian tube, uterus and efferent ducts of epididymis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA023748 , HPA053682
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION

Gene name

 SPAG1 (HGNC Symbol)

Synonyms

 CILD28, CT140, FLJ32920, HSD-3.8, SP75, TPIS

Description

 Sperm associated antigen 1 (HGNC Symbol)

Entrez gene summary

 The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q22.2

Chromosome location (bp)

 100157906 - 100259278

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104450 (version 83.38)

Entrez gene

 6674

UniProt

 Q07617 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07617

Antibodypedia

 SPAG1 antibodies

PROTEIN BROWSER
SPAG1-001
SPAG1-002
SPAG1-004
SPAG1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPAG1-001
ENSP00000373450
ENST00000388798
Q07617 [Direct mapping]
Sperm-associated antigen 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007338 [single fertilization]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016787 [hydrolase activity]
GO:0070286 [axonemal dynein complex assembly]
Show all
 926 aa
103.6 kDa 		No 0
SPAG1-002
ENSP00000427716
ENST00000520643
Q07617 [Direct mapping]
Sperm-associated antigen 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007338 [single fertilization]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016787 [hydrolase activity]
GO:0070286 [axonemal dynein complex assembly]
Show all
 416 aa
48 kDa 		No 0
SPAG1-004
ENSP00000428070
ENST00000520508
Q07617 [Direct mapping]
Sperm-associated antigen 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007338 [single fertilization]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016787 [hydrolase activity]
GO:0070286 [axonemal dynein complex assembly]
Show all
 416 aa
48 kDa 		No 0
SPAG1-201
ENSP00000251809
ENST00000251809
Q07617 [Direct mapping]
Sperm-associated antigen 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007338 [single fertilization]
GO:0008152 [metabolic process]
GO:0015630 [microtubule cytoskeleton]
GO:0016787 [hydrolase activity]
GO:0070286 [axonemal dynein complex assembly]
Show all
 926 aa
103.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.