Expression of SQLE in cancer - Summary - The Human Protein Atlas

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SQLE

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SQLE
Gene description	Squalene epoxidase
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA018038 , HPA020762
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable), lung cancer (unfavourable), renal cancer (unfavourable) and head and neck cancer (unfavourable).
Pancreatic cancer p<0.001 Lung cancer p<0.001 Renal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018038	HPA020762

GENE INFORMATION
Gene name	SQLE
Synonyms
Description	Squalene epoxidase (HGNC Symbol)
Entrez gene summary	Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.13
Chromosome location (bp)	124998497 - 125022283
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104549 (version 83.38)
Entrez gene	6713
UniProt	Q14534 (UniProt - Evidence at protein level)
neXtProt	NX_Q14534
Antibodypedia	SQLE antibodies

PROTEIN BROWSER

SQLE-001	SQLE-002	SQLE-004	SQLE-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SQLE-001 ENSP00000265896 ENST00000265896	Q14534 [Direct mapping] Squalene monooxygenase Q9UNR6 [Target identity:100%; Query identity:100%] Squalene epoxidase; cDNA, FLJ93917, highly similar to Homo sapiens squalene epoxidase (SQLE), mRNA Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004506 [squalene monooxygenase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006695 [cholesterol biosynthetic process] GO:0006725 [cellular aromatic compound metabolic process] GO:0008203 [cholesterol metabolic process] GO:0010033 [response to organic substance] GO:0016021 [integral component of membrane] GO:0016126 [sterol biosynthetic process] GO:0016491 [oxidoreductase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	574 aa 63.9 kDa	No	4
SQLE-002 ENSP00000430331 ENST00000523430	E7EVQ6 [Direct mapping] Squalene monooxygenase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004506 [squalene monooxygenase activity] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	479 aa 53.1 kDa	No	3
SQLE-004 ENSP00000428239 ENST00000521232	E5RJH9 [Direct mapping] Squalene monooxygenase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0071949 [FAD binding] Show all	184 aa 20.4 kDa	No	0
SQLE-008 ENSP00000429916 ENST00000518931	H0YBN7 [Direct mapping] Squalene monooxygenase Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004506 [squalene monooxygenase activity] GO:0016021 [integral component of membrane] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	163 aa 18.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.